Age-related decrease in functional connectivity of the right fronto-insular cortex with the central executive and default-mode networks in adults from young to middle age
文献类型：期刊论文
| 作者 | He, Xiaoxi1; Qin, Wen1; Liu, Yong2 ; Zhang, Xinqing3; Duan, Yunyun4; Song, Jinyu1; Li, Kuncheng4; Jiang, Tianzi2; Yu, Chunshui1
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| 刊名 | NEUROSCIENCE LETTERS
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| 出版日期 | 2013-06-07 |
| 卷号 | 544页码:74-79 |
| 关键词 | Middle age Executive control network Default-mode network Fronto-insular cortex Functional connectivity |
| 英文摘要 | The right fronto-insular cortex (rFIC) is a core node of the salience network (SN) and plays a critical role in switching between the central executive network (CEN) and the default-mode network (DMN), an important function in cognitive processing. In the present study, we tested the hypothesis that the functional connectivity (FC) between the rFIC and the CEN and DMN may decrease with age in adults from youth to middle age given that the intra- and inter-network FCs of the three networks decline in aged people. We performed voxel-wise FC analysis based on resting state functional MRI data (171 subjects; 17-62 years of age) to investigate whether the FCs of the rFIC are associated with age in normal adults. We found age-related decreases in the positive FCs between the rFIC and the CEN and in the negative FCs between the rFIC and the DMN with and without atrophy correction. These findings suggest that the connection of the rFIC with the CEN and DMN is degraded even in middle-aged adults, which may influence the role of the rFIC in effectively switching between the CEN and DMN and may further affect cognitive function in these subjects. (c) 2013 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | RESTING-STATE FMRI ; ANTERIOR CINGULATE ; BRAIN NETWORKS ; DECLINE ; SYSTEMS ; DORSAL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320632300015 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3219]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China 4.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Xiaoxi,Qin, Wen,Liu, Yong,et al. Age-related decrease in functional connectivity of the right fronto-insular cortex with the central executive and default-mode networks in adults from young to middle age[J]. NEUROSCIENCE LETTERS,2013,544:74-79. |
| APA | He, Xiaoxi.,Qin, Wen.,Liu, Yong.,Zhang, Xinqing.,Duan, Yunyun.,...&Yu, Chunshui.(2013).Age-related decrease in functional connectivity of the right fronto-insular cortex with the central executive and default-mode networks in adults from young to middle age.NEUROSCIENCE LETTERS,544,74-79. |
| MLA | He, Xiaoxi,et al."Age-related decrease in functional connectivity of the right fronto-insular cortex with the central executive and default-mode networks in adults from young to middle age".NEUROSCIENCE LETTERS 544(2013):74-79. |
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来源：自动化研究所
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