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Abnormal topological organization of structural brain networks in schizophrenia

文献类型：期刊论文

作者Zhang, Yuanchao1,2; Lin, Lei2,8; Lin, Ching-Po3,4; Zhou, Yuan5; Chou, Kun-Hsien3; Lo, Chun-Yi3,4; Su, Tung-Ping6,7; Jiang, Tianzi1,2,9
刊名SCHIZOPHRENIA RESEARCH
出版日期2012-11-01
卷号141期号:2-3页码:109-118
关键词Schizophrenia Structural network Cortical thickness Topological organization Betweenness centrality
英文摘要Schizophrenia is a debilitating mental disorder characterized by disturbances of thought and emotion as well as neurocognitive deficits. It is hypothesized that the core symptoms of schizophrenia arise from the inability to integrate neural processes segregated across distributed brain regions. Graph theory allows us to verify this hypothesis at large-scale structural network level. In this study, a sample of 101 schizophrenic patients and 101 healthy controls was included. We sought to investigate the abnormality of network topological organization in patients with schizophrenia by using the cortical thickness measurement from magnetic resonance imaging. Brain networks were constructed by thresholding cortical thickness correlation matrices of 78 regions and analyzed using graph theoretical approaches. Compared to healthy controls, patients showed increased characteristic path length and clustering coefficient in the structural cortical networks. Moreover, schizophrenia patients were associated with reduced nodal centrality in several regions of the default network and increased nodal centrality mainly in primary cortex and paralimbic cortex regions. These findings suggest that the structural networks of schizophrenic patients have a less optimal topological organization, resulting in reduced capacity to integrate information across brain regions. (C) 2012 Elsevier B.V. All rights reserved.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]SMALL-WORLD NETWORKS ; HUMAN CEREBRAL-CORTEX ; MAGNETIC-RESONANCE IMAGES ; SURFACE-BASED ANALYSIS ; CORTICAL THICKNESS ; FUNCTIONAL CONNECTIVITY ; 1ST-EPISODE SCHIZOPHRENIA ; ANATOMICAL CONNECTIVITY ; COGNITIVE DYSMETRIA ; ONSET SCHIZOPHRENIA
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000309511300001
源URL[http://ir.ia.ac.cn/handle/173211/3226]  
专题自动化研究所_脑网络组研究中心
作者单位1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
3.Natl Yang Ming Univ, Inst Neurosci, Brain Connect Lab, Taipei 112, Taiwan
4.Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei 112, Taiwan
5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100190, Peoples R China
6.Taipei Vet Gen Hosp, Dept Psychiat, Taipei 112, Taiwan
7.Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei 112, Taiwan
8.Zhejiang Univ, Dept Math, Hangzhou 310027, Peoples R China
9.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式
GB/T 7714		 Zhang, Yuanchao,Lin, Lei,Lin, Ching-Po,et al. Abnormal topological organization of structural brain networks in schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2012,141(2-3):109-118.
APA Zhang, Yuanchao.,Lin, Lei.,Lin, Ching-Po.,Zhou, Yuan.,Chou, Kun-Hsien.,...&Jiang, Tianzi.(2012).Abnormal topological organization of structural brain networks in schizophrenia.SCHIZOPHRENIA RESEARCH,141(2-3),109-118.
MLA Zhang, Yuanchao,et al."Abnormal topological organization of structural brain networks in schizophrenia".SCHIZOPHRENIA RESEARCH 141.2-3(2012):109-118.

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来源：自动化研究所

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