Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals
文献类型：期刊论文
| 作者 | Yuan, Kai2; Qin, Wei2; Liu, Jixin2; Guo, Qian2; Dong, Minghao2; Sun, Jinbo2; Zhang, Yi2; Liu, Peng2; Wang, Wei3; Wang, Yarong3 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2010-06-14 |
| 卷号 | 477期号:1页码:37-42 |
| 关键词 | Heroin Resting-state Graph theory analysis |
| 英文摘要 | Although previous studies reported addiction-related alteration in resting-state brain connectivity, it is unclear whether these resting-state connectivity alterations were associated with chronic heroin use. In the current study, graph theory analysis (GTA) was applied to detect abnormal topological properties in heroin-dependent individuals. Several statistical parameters, such as degree (D), clustering coefficient (C) and shortest absolute path length (L), were included to test whether or not there was significant correlation between these parameters and the duration of heroin use. Our results demonstrated abnormal topological properties in several brain regions among our heroin-dependent subjects. Some of these regions are key areas of drug addiction-related circuits (control, reward, motivation/drive and memory), while others are involved in stress regulation. In addition, the duration of heroin use was positively correlated with the parameter Din the right parahippocampal gyrus, left putamen and bilateral cerebellum, but negatively correlated with the parameter L in the same regions. Our findings suggested that there is abnormal functional organization in heroin-dependent individuals and that the duration of heroin use is a critical factor leading to the altered brain connectivity. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | COCAINE ADDICTION ; STRESS ; CONNECTIVITY ; DRUG ; FMRI ; SENSITIVITY ; HYPOTHESIS ; DISEASE ; RELAPSE ; CORTEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000279045600009 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3913]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China 3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China 4.Univ Florida, McKnight Brain Inst, Dept Psychiat & Neurosci, Gainesville, FL 32610 USA |
| 推荐引用方式 GB/T 7714 | Yuan, Kai,Qin, Wei,Liu, Jixin,et al. Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals[J]. NEUROSCIENCE LETTERS,2010,477(1):37-42. |
| APA | Yuan, Kai.,Qin, Wei.,Liu, Jixin.,Guo, Qian.,Dong, Minghao.,...&Tian, Jie.(2010).Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals.NEUROSCIENCE LETTERS,477(1),37-42. |
| MLA | Yuan, Kai,et al."Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals".NEUROSCIENCE LETTERS 477.1(2010):37-42. |
入库方式： OAI收割
来源：自动化研究所
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