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Distinct resting-state brain activities in heroin-dependent individuals

文献类型：期刊论文

作者Zhang, Yi1,2; Tian, Jie1,3; Yuan, Kai1; Liu, Peng1; Zhuo, Lu1; Qin, Wei1; Zhao, Liyan4; Liu, Jixin1; von Deneen, Karen M.1,2; Klahr, Nelson J.2
刊名BRAIN RESEARCH
出版日期2011-07-21
卷号1402页码:46-53
关键词Heroin-dependent individuals Pattern classification Multi-voxel pattern analysis (MVPA) Non-negative matrix factorization (NMF) Support vector machine (SVM)
英文摘要Previous functional imaging studies on heroin addicts have focused on abnormal brain functions based on specific tasks, while few fMRI studies concentrated on the resting-state abnormalities of heroin-dependent individuals. In the current study, we applied the pattern classification technique, which employs the feature extraction method of non-negative matrix factorization (NMF) and a support vector machine (SVM) classifier. Its main purpose was to characterize the discrepancy in activation patterns between heroin-dependent individuals and healthy subjects during the resting state. The results displayed a high accuracy in the activation pattern differences of the two groups, which included the orbitofrontal cortex pm, cingulate gyrus, frontal and para-limbic regions such as the anterior cingulate cortex (ACC), hippocampal/parahippocampal region, amygdala, caudate, putamen, as well as the posterior insula and thalamus. These findings indicate that significant biomarkers exist among the network of circuits that are involved in drug abuse. The implications from our study may help explain the behavioral and neuropsychological deficits in heroin-dependent individuals and shed light on the mechanisms underlying heroin addiction. (C) 2011 Elsevier B.V. All rights reserved.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]STRIATAL DOPAMINE RELEASE ; SUPPORT VECTOR MACHINES ; HUMAN VISUAL-CORTEX ; COCAINE ADDICTION ; ORBITOFRONTAL CORTEX ; NEUROIMAGING EVIDENCE ; SUBJECTIVE RESPONSES ; DRUG-ADDICTION ; FMRI DATA ; STRESS
收录类别SCI
语种英语
WOS记录号WOS:000293312300006
源URL[http://ir.ia.ac.cn/handle/173211/3925]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
2.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32610 USA
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yi,Tian, Jie,Yuan, Kai,et al. Distinct resting-state brain activities in heroin-dependent individuals[J]. BRAIN RESEARCH,2011,1402:46-53.
APA Zhang, Yi.,Tian, Jie.,Yuan, Kai.,Liu, Peng.,Zhuo, Lu.,...&Liu, Yijun.(2011).Distinct resting-state brain activities in heroin-dependent individuals.BRAIN RESEARCH,1402,46-53.
MLA Zhang, Yi,et al."Distinct resting-state brain activities in heroin-dependent individuals".BRAIN RESEARCH 1402(2011):46-53.

入库方式： OAI收割

来源：自动化研究所

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