Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography
文献类型：期刊论文
| 作者 | Ma, Xibo ; Liu, Zhaofei; Yang, Xin; Gao, Qiujuan; Zhu, Shouping; Qin, Chenghu; Liu, Kai; Zhang, Bo; Han, Dong; Wang, Fan2
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| 刊名 | MOLECULAR IMAGING
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| 出版日期 | 2011-07-01 |
| 卷号 | 10期号:4页码:278-283 |
| 英文摘要 | The purpose of this study was to noninvasively monitor the therapeutic efficacy of cyclophosphamide (CTX) in a mouse model by dual-modality molecular imaging: positron emission tomography (PET) and bioluminescence imaging (BLI). Firefly luciferase (fLuc) transfected HCC-LM3-fLuc human hepatocellular carcinoma cells were injected subcutaneously into BALB/c nude mice to establish the experimental tumor model. Two groups of HCC-LM3-fLuc tumor-bearing mice (n = 7 per group) were treated with saline or CTX (100 mg/kg on days 0, 2, 5, and 7). BLI and (18)F-fluorodeoxyglucose ((18)F-FDG) PET scans were done to evaluate the treatment efficacy. CTX induced a 25.25 +/- 13.13% and 35.91 +/- 25.85% tumor growth inhibition rate on days 9 and 12 posttreatment, respectively, as determined by BLI. A good linear correlation was found between the tumor sizes measured by caliper and the BLI signals determined by optical imaging (R(2) = .9216). (18)F-FDG imaging revealed a significant uptake reduction in the tumors of the CTX-treated group compared to that in the saline control group (5.30 +/- 1.97 vs 3.00 +/- 2.11% ID/g) on day 16 after CTX treatment. Dual-modality molecular imaging using BLI and small-animal PET can play important roles in the process of chemotherapy and will provide noninvasive and reliable monitoring of the therapeutic response. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | HEPATOCELLULAR-CARCINOMA ; METASTASIS ; INHIBITION ; GROWTH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294562600006 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3927]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Med Image Proc Grp, Inst Automat, Beijing 100190, Peoples R China 2.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China 3.Northeastern Univ, Sino Dutch Biomed & Informat Engn Sch, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xibo,Liu, Zhaofei,Yang, Xin,et al. Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography[J]. MOLECULAR IMAGING,2011,10(4):278-283. |
| APA | Ma, Xibo.,Liu, Zhaofei.,Yang, Xin.,Gao, Qiujuan.,Zhu, Shouping.,...&Tian, Jie.(2011).Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography.MOLECULAR IMAGING,10(4),278-283. |
| MLA | Ma, Xibo,et al."Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography".MOLECULAR IMAGING 10.4(2011):278-283. |
入库方式： OAI收割
来源：自动化研究所
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