Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals
文献类型：期刊论文
| 作者 | Yuan, Kai2; Qin, Wei2; Dong, Minghao2; Liu, Jixin2; Sun, Jinbo2; Liu, Peng2; Zhang, Yi2; Wang, Wei3; Wang, Yarong3; Li, Qiang3
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| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2010-09-27 |
| 卷号 | 482期号:2页码:101-105 |
| 关键词 | Heroin Voxel-based morphometry Resting-state |
| 英文摘要 | Previous neuroimaging studies have demonstrated both structural and functional damages in heroin-dependent individuals. However, few studies investigated gray matter deficits and abnormal resting-state networks together in heroin-dependent individuals. In the present study, voxel-based morphometry (VBM) was used to identify brain regions with gray matter density reduction. Resting-state fMRI connectivity analysis was employed to assess potential functional abnormalities during resting-state. All clinical significances were investigated by examining their association with duration of heroin use. Compared with healthy subjects, heroin-dependent individuals showed significant reduction in gray matter density in the right dorsolateral prefrontal cortex (DLPFC) and a decrease in resting-state functional connectivity between the right DLPFC and left inferior parietal lobe (IPL). The gray matter density of the right DLPFC and its resting-state functional connectivity with the left IPL both showed significantly negative correlation with duration of heroin use, which were likely to be related to the functional impairments in decision-making and cognitive control exhibited by heroin-dependent individuals. Our findings demonstrated that long heroin dependence impairs the right DLPFC in heroin-dependent individuals, including structural deficits and resting-state functional impairments. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | VOXEL-BASED MORPHOMETRY ; FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ; OPIATE DEPENDENCE ; DEFAULT MODE ; FMRI ; BRAIN ; CUES ; NETWORKS ; COCAINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281473000005 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3946]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China 3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China 4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China 5.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32610 USA 6.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL 32610 USA |
| 推荐引用方式 GB/T 7714 | Yuan, Kai,Qin, Wei,Dong, Minghao,et al. Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals[J]. NEUROSCIENCE LETTERS,2010,482(2):101-105. |
| APA | Yuan, Kai.,Qin, Wei.,Dong, Minghao.,Liu, Jixin.,Sun, Jinbo.,...&Tian, Jie.(2010).Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals.NEUROSCIENCE LETTERS,482(2),101-105. |
| MLA | Yuan, Kai,et al."Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals".NEUROSCIENCE LETTERS 482.2(2010):101-105. |
入库方式： OAI收割
来源：自动化研究所
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