In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models
文献类型：期刊论文
| 作者 | Liu, Junting1; Wang, Yabin2; Qu, Xiaochao1; Li, Xiangsi1; Ma, Xiaopeng1; Han, Runqiang1; Hu, Zhenhua1 ; Chen, Xueli1; Sun, Dongdong2; Zhang, Rongqing2
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| 刊名 | OPTICS EXPRESS
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| 出版日期 | 2010-06-07 |
| 卷号 | 18期号:12页码:13102-13113 |
| 英文摘要 | Bioluminescence tomography (BLT) is a new optical molecular imaging modality, which can monitor both physiological and pathological processes by using bioluminescent light-emitting probes in small living animal. Especially, this technology possesses great potential in drug development, early detection, and therapy monitoring in preclinical settings. In the present study, we developed a dual modality BLT prototype system with Micro-computed tomography (MicroCT) registration approach, and improved the quantitative reconstruction algorithm based on adaptive hp finite element method (hp-FEM). Detailed comparisons of source reconstruction between the heterogeneous and homogeneous mouse models were performed. The models include mice with implanted luminescence source and tumor-bearing mice with firefly luciferase report gene. Our data suggest that the reconstruction based on heterogeneous mouse model is more accurate in localization and quantification than the homogeneous mouse model with appropriate optical parameters and that BLT allows super-early tumor detection in vivo based on tomographic reconstruction of heterogeneous mouse model signal. (C) 2010 Optical Society of America |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Optics |
| 研究领域[WOS] | Optics |
| 关键词[WOS] | SOURCE RECONSTRUCTION ; IMAGE-RECONSTRUCTION ; LIGHT ; PROPAGATION ; ALGORITHM ; TISSUE ; CELL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000278527700115 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3947]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China 2.Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA |
| 推荐引用方式 GB/T 7714 | Liu, Junting,Wang, Yabin,Qu, Xiaochao,et al. In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models[J]. OPTICS EXPRESS,2010,18(12):13102-13113. |
| APA | Liu, Junting.,Wang, Yabin.,Qu, Xiaochao.,Li, Xiangsi.,Ma, Xiaopeng.,...&Tian, Jie.(2010).In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models.OPTICS EXPRESS,18(12),13102-13113. |
| MLA | Liu, Junting,et al."In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models".OPTICS EXPRESS 18.12(2010):13102-13113. |
入库方式： OAI收割
来源：自动化研究所
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