Time-Varied Characteristics of Acupuncture Effects in fMRI Studies
文献类型：期刊论文
| 作者 | Bai, Lijun1; Qin, Wei1; Tian, Jie1,2 ; Liu, Peng3; Li, LinLing1; Chen, Peng4; Dai, Jianping5; Craggs, Jason G.6; von Deneen, Karen M.7,8; Liu, Yijun7,8
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| 刊名 | HUMAN BRAIN MAPPING
 |
| 出版日期 | 2009-11-01 |
| 卷号 | 30期号:11页码:3445-3460 |
| 关键词 | acupuncture resting baseline condition time-varied responses functional magnetic resonance imaging |
| 英文摘要 | When studying the neural responses to acupuncture with a block-designed paradigm, its temporal dynamics predicted by the general linear model (GLM) conforms to typical "on-off" variations during a limited period of the experiment manipulation. Despite a lack of direct evidence associating its psychophysiological response, numerous clinical reports suggest that acupuncture can provide pain relief beyond a needling session. Therefore, a typical GLM analysis may be insensitive or inappropriate for identifying altered neural responses resulting from acupuncture. We developed a new approach to investigate the dynamics underlying sustained effects of acupuncture. Specifically, we designed two separate models to evaluate the baseline activities (prior to stimulation) and neural activities in sequential epochs, using three block-designed functional runs: acupuncture at acupoint ST36, nonmeridian point (NMP) stimulation, and a visual task. We found that the activity patterns during rest were associated with the stimulus types and that the resting activities might be even higher than that of stimulation phases. Such effects of the elevated activity during rest may reduce or eliminate the activity during stimulus conditions or even reverse the sign of brain activation using conventional GLM analysis. Moreover, such sustained responses, followed by acupuncture at ST36 and NMP, exhibited distinct patterns in wide brain structures, particularly in the limbic system and brainstem. These findings may pose great implications for the design and interpretation of a range of acupuncture neuroimaging studies. Hum Brain Mapp 30:3445-3460, 2009. (C) 2009 Wiley-Liss, Inc. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | INDEPENDENT COMPONENT ANALYSIS ; FUNCTIONAL MRI ; HUMAN BRAIN ; CORTICAL REPRESENTATION ; RETICULAR-FORMATION ; NEURAL MECHANISMS ; PERCEIVED PAIN ; DEFAULT MODE ; STIMULATION ; ACTIVATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271565300001 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3988]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Elect Engn, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China 3.Northeastern Univ, Sch Sinodutch Biomed & Informat Engn, Shenyang, Liaoning, Peoples R China 4.Capital Med Univ, Beijing Tradit Chinese Med Hosp, Beijing, Peoples R China 5.Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China 6.Univ Florida, Gainesville, FL USA 7.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL USA 8.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL USA |
| 推荐引用方式 GB/T 7714 | Bai, Lijun,Qin, Wei,Tian, Jie,et al. Time-Varied Characteristics of Acupuncture Effects in fMRI Studies[J]. HUMAN BRAIN MAPPING,2009,30(11):3445-3460. |
| APA | Bai, Lijun.,Qin, Wei.,Tian, Jie.,Liu, Peng.,Li, LinLing.,...&Liu, Yijun.(2009).Time-Varied Characteristics of Acupuncture Effects in fMRI Studies.HUMAN BRAIN MAPPING,30(11),3445-3460. |
| MLA | Bai, Lijun,et al."Time-Varied Characteristics of Acupuncture Effects in fMRI Studies".HUMAN BRAIN MAPPING 30.11(2009):3445-3460. |
入库方式： OAI收割
来源：自动化研究所
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