Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation
文献类型：期刊论文
| 作者 | Chi, Chongwei1 ; Ye, Jinzuo1; Ding, Haolong2; He, De2; Huang, Wenhe2; Zhang, Guo-Jun2; Tian, Jie1
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| 刊名 | PLOS ONE
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| 出版日期 | 2013-12-16 |
| 卷号 | 8期号:12页码:- |
| 英文摘要 | Assessment of the sentinel lymph node (SLN) in patients with early stage breast cancer is vital in selecting the appropriate surgical approach. However, the existing methods, including methylene blue and nuclides, possess low efficiency and effectiveness in mapping SLNs, and to a certain extent exert side effects during application. Indocyanine green (ICG), as a fluorescent dye, has been proved reliable usage in SLN detection by several other groups. In this paper, we introduce a novel surgical navigation system to detect SLN with ICG. This system contains two charge-coupled devices (CCD) to simultaneously capture real-time color and fluorescent video images through two different bands. During surgery, surgeons only need to follow the fluorescence display. In addition, the system saves data automatically during surgery enabling surgeons to find the registration point easily according to image recognition algorithms. To test our system, 5 mice and 10 rabbits were used for the preclinical setting and 22 breast cancer patients were utilized for the clinical evaluation in our experiments. The detection rate was 100% and an average of 2.7 SLNs was found in 22 patients. Our results show that the usage of our surgical navigation system with ICG to detect SLNs in breast cancer patients is technically feasible. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | NEAR-INFRARED FLUORESCENCE ; CELL-PENETRATING PEPTIDES ; BIOPSY ; TRIAL ; SURGERY ; DYE ; IDENTIFICATION ; DISSECTION ; TRANSLATION ; ANGIOGRAPHY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000328735700144 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3999]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing, Peoples R China 2.Shantou Univ, Coll Med, Canc Hosp, Breast Ctr, Shantou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chi, Chongwei,Ye, Jinzuo,Ding, Haolong,et al. Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation[J]. PLOS ONE,2013,8(12):-. |
| APA | Chi, Chongwei.,Ye, Jinzuo.,Ding, Haolong.,He, De.,Huang, Wenhe.,...&Tian, Jie.(2013).Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation.PLOS ONE,8(12),-. |
| MLA | Chi, Chongwei,et al."Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation".PLOS ONE 8.12(2013):-. |
入库方式： OAI收割
来源：自动化研究所
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