Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer
文献类型：期刊论文
| 作者 | Jin, Yushen1 ; Li, Yanyan1; Ma, Xibo3; Zha, Zhengbao1; Shi, Liangliang3; Tian, Jie3; Dai, Zhifei2
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| 刊名 | BIOMATERIALS
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| 出版日期 | 2014-07-01 |
| 卷号 | 35期号:22页码:5795-5804 |
| 关键词 | Photothermal therapy Photoacoustic imaging CF imaging Polypyrrole Tantalum oxide nanoparticle |
| 英文摘要 | A nanotheranostic agent has been readily fabricated by encapsulating tantalum oxide (TaOx) nanoparticles (NPs) into polypyrrole (PPy) NPs via a facile one-step chemical oxidation polymerization for bimodal imaging guided photothermal ablation of tumor. It was proved that the obtained composite nanoparticles (TaOx@PPy NPs) with an average diameter around 45 nm could operate as an efficient bimodal contrast agent to simultaneously enhance X-ray CT and photoacoustic (PA) imaging greatly in vivo. Systemically administered TaOx@PPy NPs could passively accumulate at the tumor site during the blood circulation, which was proved by both CT and PA imaging. In addition, the in vivo therapeutic examinations showed that TaOx@PPy NPs exhibited significant photothermal cytotoxicity under near infrared laser irradiation. The tumor growth inhibition was evaluated to be 66.5% for intravenously injection and 100% for intratumoral injection, respectively. This versatile agent can be developed as a smart and promising nanoplatform that integrates multiple capabilities for both accurate diagnosing and precise locating of cancerous tissue, as well as effective photoablation of tumor. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | SENTINEL LYMPH-NODE ; COMPUTED-TOMOGRAPHY ; GOLD NANOCAGES ; MAGNETIC-RESONANCE ; PHOTOACOUSTIC TOMOGRAPHY ; CARBON NANOTUBES ; GRAPHENE OXIDE ; THERAPY ; ULTRASOUND ; NANORODS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336694700016 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4032]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China 2.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Yushen,Li, Yanyan,Ma, Xibo,et al. Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer[J]. BIOMATERIALS,2014,35(22):5795-5804. |
| APA | Jin, Yushen.,Li, Yanyan.,Ma, Xibo.,Zha, Zhengbao.,Shi, Liangliang.,...&Dai, Zhifei.(2014).Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer.BIOMATERIALS,35(22),5795-5804. |
| MLA | Jin, Yushen,et al."Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer".BIOMATERIALS 35.22(2014):5795-5804. |
入库方式： OAI收割
来源：自动化研究所
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