Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies
文献类型：期刊论文
| 作者 | Cao, Xin1; Chen, Xueli1; Kang, Fei2; Lin, Yenan1; Liu, Muhan1; Hu, Hao3; Nie, Yongzhan3; Wu, Kaichun3; Wang, Jing2; Liang, Jimin1 |
| 刊名 | BIOMEDICAL OPTICS EXPRESS
 |
| 出版日期 | 2014-10-01 |
| 卷号 | 5期号:10页码:3660-3670 |
| 英文摘要 | By integrating the clinically used endoscope with the emerging Cerenkov luminescence imaging (CLI) technology, a new endoscopic Cerenkov luminescence imaging (ECLI) system was developed. The aim is to demonstrate the potential of translating CLI to clinical studies of gastrointestinal (GI) tract diseases. We systematically evaluated the feasibility and performance of the developed ECLI system with a series of in vitro and pseudotumor experiments. The ECLI system is comprised of an electron multiplying charge coupled device (EMCCD) camera coupled with a clinically used endoscope via an optical adapter. A 1951-USAF test board was used to measure the white-light lateral resolution, while a homemade test chart filled with Ga-68 was employed to measure the CL lateral resolution. Both in vitro and pseudotumor experiments were conducted to obtain the sensitivity of the ECLI system. The results were validated with that of CLI using EMCCD only, and the relative attenuation ratio of the ECLI system was calculated. Results showed that The white-light lateral resolution of the ECLI system was 198 mu m, and the luminescent lateral resolution was better than 1 mm. Sensitivity experiments showed a theoretical sensitivity of 0.186 KBq / mu l (5.033x10(-3) mu Ci / mu l) and 1.218 KBq / mu l (32.922x10(-3) mu Ci / mu l) for the in vitro and pseudotumor studies, respectively. The relative attenuation ratio of ECLI to CLI was about 96%. The luminescent lateral resolution of the ECLI system was comparable with that of positron emission tomography (PET). The pseudotumor study illustrated the feasibility and applicability of the ECLI system in living organisms, indicating the potential for translating the CLI technology to the clinic. (C)2014 Optical Society of America |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | GASTROINTESTINAL STROMAL TUMORS ; CANCER STATISTICS ; RADIATION ; F-18-FDG ; PET/CT ; CT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343135200032 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4034]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Engn Res Ctr Mol & Neuroimaging, Sch Life Sci & Technol, Minist Educ, Xian 710071, Shaanxi, Peoples R China 2.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Xin,Chen, Xueli,Kang, Fei,et al. Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies[J]. BIOMEDICAL OPTICS EXPRESS,2014,5(10):3660-3670. |
| APA | Cao, Xin.,Chen, Xueli.,Kang, Fei.,Lin, Yenan.,Liu, Muhan.,...&Tian, Jie.(2014).Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies.BIOMEDICAL OPTICS EXPRESS,5(10),3660-3670. |
| MLA | Cao, Xin,et al."Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies".BIOMEDICAL OPTICS EXPRESS 5.10(2014):3660-3670. |
入库方式： OAI收割
来源：自动化研究所
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