Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification
文献类型：期刊论文
| 作者 | Zhang, Jun1; Chen, Duofang1; Liang, Jimin1; Xue, Huadan2; Lei, Jing2; Wang, Qin2; Chen, Dongmei1; Meng, Ming2; Jin, Zhengyu2; Tian, Jie1,3
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| 刊名 | BIOMEDICAL OPTICS EXPRESS
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| 出版日期 | 2014-06-01 |
| 卷号 | 5期号:6页码:1861-1876 |
| 英文摘要 | Combining two or more imaging modalities to provide complementary information has become commonplace in clinical practice and in preclinical and basic biomedical research. By incorporating the structural information provided by computed tomography (CT) or magnetic resonance imaging (MRI), the ill poseness nature of bioluminescence tomography (BLT) can be reduced significantly, thus improve the accuracies of reconstruction and in vivo quantification. In this paper, we present a small animal imaging system combining multi-view and multi-spectral BLT with MRI. The independent MRI-compatible optical device is placed at the end of the clinical MRI scanner. The small animal is transferred between the light tight chamber of the optical device and the animal coil of MRI via a guide rail during the experiment. After the optical imaging and MRI scanning procedures are finished, the optical images are mapped onto the MRI surface by interactive registration between boundary of optical images and silhouette of MRI. Then, incorporating the MRI structural information, a heterogeneous reconstruction algorithm based on finite element method (FEM) with L-1 normalization is used to reconstruct the position, power and region of the light source. In order to validate the feasibility of the system, we conducted experiments of nude mice model implanted with artificial light source and quantitative analysis of tumor inoculation model with MDA-231-GFP-luc. Preliminary results suggest the feasibility and effectiveness of the prototype system. (C) 2014 Optical Society of America |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | DIFFUSE OPTICAL TOMOGRAPHY ; FLUORESCENCE TOMOGRAPHY ; IMAGE-RECONSTRUCTION ; RADIATIVE-TRANSFER ; MOUSE MODELS ; BREAST ; TISSUE ; SIMULATION ; ALGORITHM ; APPROXIMATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337503900013 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4036]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Beijing Union Med Coll Hosp, Beijing 100730, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jun,Chen, Duofang,Liang, Jimin,et al. Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification[J]. BIOMEDICAL OPTICS EXPRESS,2014,5(6):1861-1876. |
| APA | Zhang, Jun.,Chen, Duofang.,Liang, Jimin.,Xue, Huadan.,Lei, Jing.,...&Tian, Jie.(2014).Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification.BIOMEDICAL OPTICS EXPRESS,5(6),1861-1876. |
| MLA | Zhang, Jun,et al."Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification".BIOMEDICAL OPTICS EXPRESS 5.6(2014):1861-1876. |
入库方式： OAI收割
来源：自动化研究所
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