ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo
文献类型：期刊论文
| 作者 | Xin, Jing1; Zhan, Yonghua1; Liu, Muhan1; Hu, Hao3; Xia, Limin3; Nie, Yongzhan3; Wu, Kaichun3; Liang, Jimin1; Tian, Jie1,2
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| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2013-08-19 |
| 卷号 | 336期号:2页码:260-269 |
| 关键词 | ApoG2 Gastric cancer Bioluminescence imaging Endoplasmic reticulum stress |
| 英文摘要 | Apogossypolone (ApoG2), a potent small molecular inhibitor of Bcl-2 family proteins, is reported to have a significant anti-cancer effect in several types of cancers, but it has not been investigated in gastric cancer. In this study, we demonstrate in vitro and in vivo that ApoG2 inhibits human gastric cancer. Gastric carcinoma cell growth and proliferation was significantly hampered in vitro, as measured by MTT and colony formation assays. Real-time bioluminescence imaging indicated that ApoG2 causes tumor growth delay in a murine xenograft model. Further studies revealed that the ApoG2 induced apoptosis in gastric cancer cells was associated with the endoplasmic reticulum stress-induced apoptosis pathway. Conclusively, our results indicate that ApoG2 may be a promising agent for gastric cancer therapy. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | ENDOPLASMIC-RETICULUM STRESS ; BCL-2 FAMILY PROTEINS ; MULTIDRUG-RESISTANCE ; DRUG DEVELOPMENT ; PROSTATE-CANCER ; CYCLE ARREST ; TUMOR-GROWTH ; GOSSYPOL ; APOGOSSYPOLONE ; INHIBITOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322089400003 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4042]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Inst Digest Dis, Xian 710032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xin, Jing,Zhan, Yonghua,Liu, Muhan,et al. ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo[J]. CANCER LETTERS,2013,336(2):260-269. |
| APA | Xin, Jing.,Zhan, Yonghua.,Liu, Muhan.,Hu, Hao.,Xia, Limin.,...&Tian, Jie.(2013).ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo.CANCER LETTERS,336(2),260-269. |
| MLA | Xin, Jing,et al."ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo".CANCER LETTERS 336.2(2013):260-269. |
入库方式： OAI收割
来源：自动化研究所
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