Noninvasive Estimation of the Input Function for Dynamic Mouse F-18-FDG MicroPET Studies
文献类型：期刊论文
| 作者 | Mu, Wei ; Chen, Zhe; Dai, Xiaoqian; Tian, Jie
|
| 刊名 | IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
 |
| 出版日期 | 2013-11-01 |
| 卷号 | 60期号:11页码:3103-3112 |
| 关键词 | Bayesian penalty term constraint nonnegative matrix factorization (CNMF) delay and dispersion effects input function partial-volume and spillover effects |
| 英文摘要 | A new noninvasive estimation method for the plasma time-activity curve, i.e., input function (IF) of the tracer kinetic model in dynamic F-18-FDG microPET mouse studies, is proposed and validated. This estimation method comprises of four steps. First, a novel constraint nonnegative matrix factorization segmentation algorithm was applied to extract the left ventricle (Lv) and myocardium (Myo) time activity curves (TACs). Second, we modeled the IF as a seven-parameter mathematical equation and constructed a dual-output model of the real TAC in Lv and Myo accounting for the partial-volume and spillover effects. Then, we fit the image-derived Lv and Myo TACs to the dual-output model to estimate the parameters of the IF. Finally, the IF was validated by comparing it to the gold standard IF while considering the delay and dispersion effects. Our method was verified based on 20 mice datasets from the Mouse Quantitation Program database, provided by UCLA. The error of the areas under the curves between the delayed and dispersed estimated IF and the gold standard IF was 7.237% +/- 6.742% (r = 0.969), and the error of the F-18-FDG influx constant Ki of the Myo was 4.910% +/- 6.810% (r = 0.992). The results demonstrated the effectiveness of the proposed method. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical |
| 研究领域[WOS] | Engineering |
| 关键词[WOS] | INDEPENDENT COMPONENT ANALYSIS ; POSITRON-EMISSION-TOMOGRAPHY ; PARTIAL-VOLUME CORRECTION ; BLOOD-SAMPLE ; PET IMAGES ; QUANTIFICATION ; TOOL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000325974500013 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4061]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | Chinese Acad Sci, Key Lab Mol Imaging & Funct Imaging, Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mu, Wei,Chen, Zhe,Dai, Xiaoqian,et al. Noninvasive Estimation of the Input Function for Dynamic Mouse F-18-FDG MicroPET Studies[J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,2013,60(11):3103-3112. |
| APA | Mu, Wei,Chen, Zhe,Dai, Xiaoqian,&Tian, Jie.(2013).Noninvasive Estimation of the Input Function for Dynamic Mouse F-18-FDG MicroPET Studies.IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,60(11),3103-3112. |
| MLA | Mu, Wei,et al."Noninvasive Estimation of the Input Function for Dynamic Mouse F-18-FDG MicroPET Studies".IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 60.11(2013):3103-3112. |
入库方式： OAI收割
来源：自动化研究所
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