Single photon emission computed tomography-guided Cerenkov luminescence tomography
文献类型：期刊论文
| 作者 | Hu, Zhenhua1 ; Chen, Xueli1; Liang, Jimin1; Qu, Xiaochao1; Chen, Duofang1; Yang, Weidong3; Wang, Jing3; Cao, Feng4; Tian, Jie1,2
|
| 刊名 | JOURNAL OF APPLIED PHYSICS
 |
| 出版日期 | 2012-07-15 |
| 卷号 | 112期号:2页码:- |
| 英文摘要 | Cerenkov luminescence tomography (CLT) has become a valuable tool for preclinical imaging because of its ability of reconstructing the three-dimensional distribution and activity of the radiopharmaceuticals. However, it is still far from a mature technology and suffers from relatively low spatial resolution due to the ill-posed inverse problem for the tomographic reconstruction. In this paper, we presented a single photon emission computed tomography (SPECT)-guided reconstruction method for CLT, in which a priori information of the permissible source region (PSR) from SPECT imaging results was incorporated to effectively reduce the ill-posedness of the inverse reconstruction problem. The performance of the method was first validated with the experimental reconstruction of an adult athymic nude mouse implanted with a (NaI)-I-131 radioactive source and an adult athymic nude mouse received an intravenous tail injection of (NaI)-I-131. A tissue-mimic phantom based experiment was then conducted to illustrate the ability of the proposed method in resolving double sources. Compared with the traditional PSR strategy in which the PSR was determined by the surface flux distribution, the proposed method obtained much more accurate and encouraging localization and resolution results. Preliminary results showed that the proposed SPECT-guided reconstruction method was insensitive to the regularization methods and ignored the heterogeneity of tissues which can avoid the segmentation procedure of the organs. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4739266] |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Physics, Applied |
| 研究领域[WOS] | Physics |
| 关键词[WOS] | BIOLUMINESCENCE TOMOGRAPHY ; RECONSTRUCTION ; RADIATION ; FEASIBILITY ; SIMULATION ; MODEL ; PET |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308424500136 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4071]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.Fourth Mil Med Univ, Dept Nucl Med, Xijing Hosp, Xian 710032, Peoples R China 4.Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Zhenhua,Chen, Xueli,Liang, Jimin,et al. Single photon emission computed tomography-guided Cerenkov luminescence tomography[J]. JOURNAL OF APPLIED PHYSICS,2012,112(2):-. |
| APA | Hu, Zhenhua.,Chen, Xueli.,Liang, Jimin.,Qu, Xiaochao.,Chen, Duofang.,...&Tian, Jie.(2012).Single photon emission computed tomography-guided Cerenkov luminescence tomography.JOURNAL OF APPLIED PHYSICS,112(2),-. |
| MLA | Hu, Zhenhua,et al."Single photon emission computed tomography-guided Cerenkov luminescence tomography".JOURNAL OF APPLIED PHYSICS 112.2(2012):-. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。