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Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura
文献类型：期刊论文
| 作者 | Yuan, Kai1; Zhao, Ling2; Cheng, Ping1; Yu, Dahua1,3; Zhao, Limei1; Dong, Tao1; Xing, Lihong1; Bi, Yanzhi1; Yang, Xuejuan1; von Deneen, Karen M.1 |
| 刊名 | JOURNAL OF PAIN
 |
| 出版日期 | 2013-08-01 |
| 卷号 | 14期号:8页码:836-844 |
| 关键词 | Migraine basal ganglia nucleus accumbens volume resting state |
| 英文摘要 | The aim of this study was to investigate the relevance of the basal ganglia (BG) in pathogenesis of migraine by assessing the abnormal volume and resting-state networks of the BG in migraine patients without aura (MWoA). The volume of the subsets in the BG was compared between 40 MWoA and 40 age- and gender-matched healthy controls. The resting-state functional connectivity of BG subsets with abnormal volume was also investigated. Reduced volume in the left caudate and the right nucleus accumbens (NAc) was detected in the migraine group compared with healthy controls; meanwhile, increased functional connectivity between the BG and several brain regions within nociceptive and somatosensory processing pathways was observed. Correlation analysis revealed significant correlations between the volume of the bilateral caudate and right NAc and disease duration. In addition, an increased monthly frequency of migraine attack was associated with increased functional connectivity between the bilateral caudate and left insula, and longer disease duration was correlated with increased functional connectivity between the right NAc and bilateral anterior cingulate cortex. Our results revealed abnormal volume of BG and dysfunctional dynamics during interictal resting state within pain pathways of the BG in MWoA, which validated the association between the BG and migraine. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Clinical Neurology ; Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | BRAIN-STEM ACTIVATION ; HEROIN-DEPENDENT INDIVIDUALS ; VOXEL-BASED MORPHOMETRY ; PAIN ; ABNORMALITIES ; DISEASE ; SEGMENTATION ; EXPERIENCE ; DISORDERS ; ANALGESIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323020300007 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4080]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China 3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou, Inner Mongolia, Peoples R China 4.Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Dept Radiol,Ctr Med Imaging, Chengdu, Sichuan, Peoples R China 5.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Kai,Zhao, Ling,Cheng, Ping,et al. Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura[J]. JOURNAL OF PAIN,2013,14(8):836-844. |
| APA | Yuan, Kai.,Zhao, Ling.,Cheng, Ping.,Yu, Dahua.,Zhao, Limei.,...&Tian, Jie.(2013).Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura.JOURNAL OF PAIN,14(8),836-844. |
| MLA | Yuan, Kai,et al."Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura".JOURNAL OF PAIN 14.8(2013):836-844. |
入库方式： OAI收割
来源：自动化研究所
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