Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: A resting-state fMRI study
文献类型：期刊论文
| 作者 | Zhou, Guangyu1; Liu, Peng1; Wang, Jingjing1 ; Wen, Haixia1; Zhu, Mengbo1; Zhao, Ruixia1; von Deneen, Karen M.1; Zeng, Fang2; Liang, Fanrong2; Gong, Qiyong4
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| 刊名 | MAGNETIC RESONANCE IMAGING
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| 出版日期 | 2013-07-01 |
| 卷号 | 31期号:6页码:996-1000 |
| 关键词 | Functional dyspepsia Resting-state Functional magnetic resonance imaging Functional connectivity Low-frequency fluctuation |
| 英文摘要 | Recently, there is an increasing interest in the study of the role of brain dysfunction in the pathogenesis of symptoms of functional dyspepsia (FD). More specifically, abnormal brain activities in patients with FD during the resting state have been proven by several positron emission tomography (PET) studies. Resting-state functional magnetic resonance imaging (fMRI) is also a valuable tool in investigating spontaneous brain activity abnormalities in pathological conditions. In the present study, we examined the amplitude of low-frequency fluctuations (ALFF) and fractional (f)ALFF changes in patients with FD by using fMRI. Twenty-nine patients with FD and sixteen healthy controls participated in this study. Between-group differences in ALFF/fALFF were examined using a permutation-based nonparametric test after accounting for the gender and age effects. The results revealed a significant between-group difference in fALFF but not in ALFF in multiple brain regions including the right insula, brainstem and cerebellum. Seed-based resting-state functional connectivity analysis revealed that FD patients have increased correlations between the right cerebellum and multiple brain regions including the bilateral brainstem, bilateral cerebellum, bilateral thalamus, left para-/hippocampus, left pallidum and left putamen. Furthermore, fLAFF values in the right insula were positively correlated with the severity of the disease. These findings have provided further evidence of spontaneous brain activity abnormalities in FD patients which might contribute to our understanding of the pathophysiology of the disease. (C) 2013 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | QUALITY-OF-LIFE ; BRAIN-GUT AXIS ; UNITED-STATES ; DISTENSION ; CONNECTIVITY ; POPULATION ; DISORDERS ; OPTIMIZATION ; REGISTRATION ; PREVALENCE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320818600024 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4083]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu 610075, Sichuan, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.Sichuan Univ, West China Hosp, HMRRC, Ctr Med Imaging,Dept Radiol, Chengdu 610075, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Guangyu,Liu, Peng,Wang, Jingjing,et al. Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: A resting-state fMRI study[J]. MAGNETIC RESONANCE IMAGING,2013,31(6):996-1000. |
| APA | Zhou, Guangyu.,Liu, Peng.,Wang, Jingjing.,Wen, Haixia.,Zhu, Mengbo.,...&Tian, Jie.(2013).Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: A resting-state fMRI study.MAGNETIC RESONANCE IMAGING,31(6),996-1000. |
| MLA | Zhou, Guangyu,et al."Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: A resting-state fMRI study".MAGNETIC RESONANCE IMAGING 31.6(2013):996-1000. |
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来源：自动化研究所
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