FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients
文献类型：期刊论文
| 作者 | Feng, Yuanyuan1; Bai, Lijun1; Ren, Yanshuang2; Chen, Shangjie3; Wang, Hu1; Zhang, Wensheng1 ; Tian, Jie1,4
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| 刊名 | MAGNETIC RESONANCE IMAGING
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| 出版日期 | 2012-06-01 |
| 卷号 | 30期号:5页码:672-682 |
| 关键词 | Mild cognitive impairment (MCI) fMRI Acupuncture Functional connectivity |
| 英文摘要 | The increased risk for the elderly with mild cognitive impairment (MCI) to progress to Alzheimer's disease makes it an appropriate condition for investigation. While the use of acupuncture as a complementary therapeutic method for treating MCI is popular in certain parts of the world, the underlying mechanism is still elusive. We sought to investigate the acupuncture effects on the functional connectivity throughout the entire brain in MCI patients compared to healthy controls (HC). The functional magnetic resonance imaging experiment was performed with two different paradigms, namely, deep acupuncture (DA) and superficial acupuncture (SA), at acupoint KI3. We first identified regions showing abnormal functional connectivity in the MCI group compared to HC during the resting state and subsequently tested whether these regions could be modulated by acupuncture. Then, we made the comparison of MCI vs. HC to test whether there were any specific modulatory patterns in the poststimulus resting brain between the two groups. Finally, we made the comparisons of DA vs. SA in each group to test the effect of acupuncture with different needling depths. We found the temporal regions (hippocampus, thalamus, fusiform gyms) showing abnormal functional connectivity during the resting state. These regions are implicated in memory encoding and retrieving. Furthermore, we found significant changes in functional connectivity related with the abnormal regions in MCI patients following acupuncture. Compared to MC, the correlations related with the temporal regions were enhanced in the poststimulus resting brain in MCI patients. Compared to SA, significantly increased correlations related with the temporal regions were found for the DA condition. The enhanced correlations in the memory-related brain regions following acupuncture may be related to the purported therapeutically beneficial effects of acupuncture for the treatment of MCI. The heterogeneous modulatory patterns between DA and SA may suggest that deep muscle insertion of acupuncture is necessary to achieve the appreciable clinical effect. (C) 2012 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; PHYSIOLOGICAL CONDITION ; DEMENTIA ; INTEROCEPTION ; STIMULATION ; SPECIFICITY ; MODULATION ; MEMORY ; SENSE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304228300010 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4085]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China 2.Chinese Acad Tradit Med, Dept Radiol, Guanganmen Hosp, Beijing 100053, Peoples R China 3.So Med Univ, Baoan Hosp, Dept Acupuncture & Massage, Shenzhen 518101, Peoples R China 4.Xidian Univ, Sch Elect Engn, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Yuanyuan,Bai, Lijun,Ren, Yanshuang,et al. FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients[J]. MAGNETIC RESONANCE IMAGING,2012,30(5):672-682. |
| APA | Feng, Yuanyuan.,Bai, Lijun.,Ren, Yanshuang.,Chen, Shangjie.,Wang, Hu.,...&Tian, Jie.(2012).FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients.MAGNETIC RESONANCE IMAGING,30(5),672-682. |
| MLA | Feng, Yuanyuan,et al."FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients".MAGNETIC RESONANCE IMAGING 30.5(2012):672-682. |
入库方式： OAI收割
来源：自动化研究所
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