Alterations of the default mode network in functional dyspepsia patients: a resting-state fmri study
文献类型：期刊论文
| 作者 | Liu, P.1; Zeng, F.2; Zhou, G.1 ; Wang, J.1; Wen, H.1; Von Deneen, K. M.1; Qin, W.1; Liang, F.2; Tian, J.1,3
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| 刊名 | NEUROGASTROENTEROLOGY AND MOTILITY
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| 出版日期 | 2013-06-01 |
| 卷号 | 25期号:6页码:e382-e388 |
| 关键词 | fMRI functional dyspepsia independent component analysis resting-state |
| 英文摘要 | Background Increasing brain imaging studies have emphasized the role of regional brain activity abnormalities in functional dyspepsia (FD) during the resting state. The goal of this study was to investigate the default mode network (DMN) in FD patients and healthy controls (HCs). Methods Resting-state functional magnetic resonance imaging (fMRI) scanning was carried out on 49 patients and 39 HCs. Independent component analysis (ICA) was used to isolate the DMN in each subject. Group topography of the DMN was compared to study significant alteration in FD. A correlation analysis was then performed in the FD group to investigate the effects of symptom severity and the psychological factors on the DMN. Key Results Significant spatial differences with the DMN in FD patients, compared with HCs, were mainly found in the dorsomedial prefrontal cortex (dmPFC), ventromedial prefrontal cortex (vmPFC), orbitofrontal cortex (OFC), pregenual anterior cingulate cortex (pACC), thalamus, parahippocampal gyrus, precuneus, parietal cortex, and temporal pole. Meanwhile, Nepean Dyspepsia Index (NDI) scores were positively correlated with the pACC, and was negative correlated with the OFC. However, both the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores were not correlated with any regions of interest showing differences between the FD patients and the HCs. Conclusions & Inferences These findings suggested that the DMN might indeed undergo dysfunctional changes due to the abnormal persistent activity in FD patients. To a certain extent, the changes in the DMN were related to the FD-related symptom severity. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Gastroenterology & Hepatology ; Clinical Neurology ; Neurosciences |
| 研究领域[WOS] | Gastroenterology & Hepatology ; Neurosciences & Neurology |
| 关键词[WOS] | ANTERIOR CINGULATE CORTEX ; ORBITOFRONTAL CORTEX ; ALZHEIMERS-DISEASE ; ANXIETY DISORDERS ; NEURAL RESPONSES ; BRAIN ACTIVITY ; PAIN ; MRI ; VALIDATION ; MODULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318945400002 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4090]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, P.,Zeng, F.,Zhou, G.,et al. Alterations of the default mode network in functional dyspepsia patients: a resting-state fmri study[J]. NEUROGASTROENTEROLOGY AND MOTILITY,2013,25(6):e382-e388. |
| APA | Liu, P..,Zeng, F..,Zhou, G..,Wang, J..,Wen, H..,...&Tian, J..(2013).Alterations of the default mode network in functional dyspepsia patients: a resting-state fmri study.NEUROGASTROENTEROLOGY AND MOTILITY,25(6),e382-e388. |
| MLA | Liu, P.,et al."Alterations of the default mode network in functional dyspepsia patients: a resting-state fmri study".NEUROGASTROENTEROLOGY AND MOTILITY 25.6(2013):e382-e388. |
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来源：自动化研究所
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