White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study
文献类型：期刊论文
| 作者 | Yu, Dahua1,2; Yuan, Kai1; Zhao, Ling3; Dong, Minghao1; Liu, Peng1; Yang, Xuejuan1; Liu, Jixin1; Sun, Jinbo1; Zhou, Guangyu1; Xue, Ting1 |
| 刊名 | NMR IN BIOMEDICINE
 |
| 出版日期 | 2013-09-01 |
| 卷号 | 26期号:9页码:1103-1112 |
| 关键词 | migraine without aura (MWoA) tract-based spatial statistics (TBSS) depressive symptoms corpus callosum (CC) anterior corona radiata (ACR) superior longitudinal fasciculi (SLF) |
| 英文摘要 | Previous studies have proven that migraine and depression are bidirectionally linked. However, few studies have investigated white matter (WM) integrity affected by depressive symptoms in patients suffering from migraine without aura (MWoA). Forty patients with MWoA were divided into two groups according to their self-rating depression scale (SDS) score in the present study, including 20 in the SDS (+) (SDS>49) group and 20 in the SDS (-) (SDS49) group. Forty healthy participants were also recruited as the control group. Tract-based spatial statistics analyses with multiple diffusion tensor imaging-derived indices [fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD)] were employed collectively to investigate WM integrity between all patients with MWoA and all healthy controls, between each subgroup (SDS (-) group and SDS (+) group) and healthy controls, and between the SDS (-) and SDS (+) groups. Compared with healthy controls, decreased AD was shown in several WM tracts of the whole MWoA group, SDS (-) group and SDS (+) group. In addition, compared with the SDS (-) group, the SDS (+) group showed decreased FA and increased MD and RD, with conserved AD, including the genu, body and splenium of the corpus callosum, bilateral superior longitudinal fasciculi, the right anterior corona radiata and some other WM tracts, similar to previous findings in depression disorder. Furthermore, mean FA and RD in some of the above-mentioned WM tracts in the SDS (+) group were correlated significantly with SDS scores, including the genu and splenium of the corpus callosum, the right anterior corona radiata and the superior longitudinal fasciculi. Our results suggest that WM integrity may be affected by both depression symptoms (more sensitive as RD) and migraine (more sensitive as AD). The findings may serve as a sensitive biomarker of depression severity in MWoA. Copyright (c) 2013 John Wiley & Sons, Ltd. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| 类目[WOS] | Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy |
| 研究领域[WOS] | Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy |
| 关键词[WOS] | LATE-LIFE DEPRESSION ; DORSOLATERAL PREFRONTAL CORTEX ; VOXEL-BASED MORPHOMETRY ; BIPOLAR DISORDER ; MAJOR DEPRESSION ; CORPUS-CALLOSUM ; MICROSTRUCTURAL ABNORMALITIES ; GRAY-MATTER ; DIFFUSION ; BRAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323078700007 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4096]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou, Inner Mongolia, Peoples R China 3.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Dahua,Yuan, Kai,Zhao, Ling,et al. White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study[J]. NMR IN BIOMEDICINE,2013,26(9):1103-1112. |
| APA | Yu, Dahua.,Yuan, Kai.,Zhao, Ling.,Dong, Minghao.,Liu, Peng.,...&Tian, Jie.(2013).White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study.NMR IN BIOMEDICINE,26(9),1103-1112. |
| MLA | Yu, Dahua,et al."White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study".NMR IN BIOMEDICINE 26.9(2013):1103-1112. |
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来源：自动化研究所
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