Altered topological patterns of brain networks in mild cognitive impairment and Alzheimer's disease: A resting-state fMRI study
文献类型：期刊论文
| 作者 | Liu, Zhenyu1 ; Zhang, Yumei2; Yan, Hao4,5; Bai, Lijun1; Dai, Ruwei1; Wei, Wenjuan1; Zhong, Chongguang1; Xue, Ting3; Wang, Hu1; Feng, Yuanyuan1
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| 刊名 | PSYCHIATRY RESEARCH-NEUROIMAGING
 |
| 出版日期 | 2012-05-31 |
| 卷号 | 202期号:2页码:118-125 |
| 关键词 | Alzheimer's disease Mild cognitive impairment Functional MRI Small-world network Nodal centrality |
| 英文摘要 | Recent studies have shown that cognitive and memory decline in patients with Alzheimer's disease (AD) is coupled with losses of small-world attributes. However, few studies have investigated the characteristics of the whole brain networks in individuals with mild cognitive impairment (MCI). In this functional magnetic resonance imaging (fMRI) study, we investigated the topological properties of the whole brain networks in 18 AD patients, 16 MCI patients, and 18 age-matched healthy subjects. Among the three groups, AD patients showed the longest characteristic path lengths and the largest clustering coefficients, while the small-world measures of MCI networks exhibited intermediate values. The finding was not surprising, given that MCI is considered to be the prodromal stage of AD. Compared with normal controls, MCI patients showed decreased nodal centrality mainly in the medial temporal lobe as well as increased nodal centrality in the occipital regions. In addition, we detected increased nodal centrality in the medial temporal lobe and frontal gyrus, and decreased nodal centrality mainly in the amygdala in MCI patients compared with AD patients. The results suggested a widespread rewiring in AD and MCI patients. These findings concerning AD and MCI may be an integrated reflection of reorganization of the brain networks accompanied with the cognitive decline that may lead to AD. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Clinical Neurology ; Neuroimaging ; Psychiatry |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychiatry |
| 关键词[WOS] | VOXEL-BASED MORPHOMETRY ; SMALL-WORLD NETWORKS ; COMPLEX NETWORKS ; AMNESTIC MCI ; CORTEX ; CONNECTIVITY ; CONVERSION ; MRI |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307424600005 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4109]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Tian Jie |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing 100190, Peoples R China 2.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China 3.Xidian Univ, Sch Elect Engn, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 4.Shaanxi Normal Univ, Sch Psychol, Xian 710062, Peoples R China 5.Xidian Univ, Dept Linguist, Xian 710071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhenyu,Zhang, Yumei,Yan, Hao,et al. Altered topological patterns of brain networks in mild cognitive impairment and Alzheimer's disease: A resting-state fMRI study[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2012,202(2):118-125. |
| APA | Liu, Zhenyu.,Zhang, Yumei.,Yan, Hao.,Bai, Lijun.,Dai, Ruwei.,...&Tian Jie.(2012).Altered topological patterns of brain networks in mild cognitive impairment and Alzheimer's disease: A resting-state fMRI study.PSYCHIATRY RESEARCH-NEUROIMAGING,202(2),118-125. |
| MLA | Liu, Zhenyu,et al."Altered topological patterns of brain networks in mild cognitive impairment and Alzheimer's disease: A resting-state fMRI study".PSYCHIATRY RESEARCH-NEUROIMAGING 202.2(2012):118-125. |
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来源：自动化研究所
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