Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer
文献类型：期刊论文
| 作者 | Ke, Hengte1,2,3; Yue, Xiuli3; Wang, Jinrui1,2; Xing, Sen3; Zhang, Qian4 ; Dai, Zhifei1,2; Tian, Jie5; Wang, Shumin1,2; Jin, Yushen3
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| 刊名 | SMALL
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| 出版日期 | 2014-03-01 |
| 卷号 | 10期号:6页码:1220-1227 |
| 关键词 | gold nanoshell liquid perfluorocarbon ultrasound imaging CT imaging photothermal therapy |
| 英文摘要 | The integration of multimodal contrast-enhanced diagnostic imaging and therapeutic capabilities could utilize imaging guided therapy to plan the treatment strategy based on the diagnostic results and to guide/monitor the therapeutic procedures. Herein, gold nanoshelled perfluorooctylbromide (PFOB) nanocapsules with PEGylation (PGsP NCs) are constructed by oil-in-water emulsion method to form polymeric PFOB nanocapsules, followed by the formation of PEGylated gold nanoshell on the surface. PGsP NCs could not only provide excellent contrast enhancement for dual modal ultrasound and CT imaging in vitro and in vivo, but also serve as efficient photoabsorbers for photothermal ablation of tumors on xenografted nude mouse model. To our best knowledge, this is the first report of gold nanoshell serving as both CT contrast agents and photoabsorbers for photothermal therapy. The novel multifunctional nanomedicine would be of great value to offer more comprehensive diagnostic information to guide more accurate and effective cancer therapy. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | RAY COMPUTED-TOMOGRAPHY ; CONTRAST AGENTS ; MACROPHAGE ENDOCYTOSIS ; OPTICAL-PROPERTIES ; NANOPARTICLES ; HYPERTHERMIA ; RADIATION ; NANOCAGES ; NANORODS ; TUMORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000333538000024 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4111]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China 2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China 3.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Sch Life Sci & Technol, Harbin 150080, Peoples R China 4.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 5.Chinese Acad Sci, Intelligent Med Ctr, Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ke, Hengte,Yue, Xiuli,Wang, Jinrui,et al. Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer[J]. SMALL,2014,10(6):1220-1227. |
| APA | Ke, Hengte.,Yue, Xiuli.,Wang, Jinrui.,Xing, Sen.,Zhang, Qian.,...&Jin, Yushen.(2014).Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer.SMALL,10(6),1220-1227. |
| MLA | Ke, Hengte,et al."Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer".SMALL 10.6(2014):1220-1227. |
入库方式： OAI收割
来源：自动化研究所
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