A new strategy in drug design of chinese medicine: Theory, method and techniques
文献类型：期刊论文
| 作者 | Yang Hong-jun ; Shen Dan1; Xu Hai-yu1; Lu Peng1,2
|
| 刊名 | CHINESE JOURNAL OF INTEGRATIVE MEDICINE
 |
| 出版日期 | 2012-11-01 |
| 卷号 | 18期号:11页码:803-806 |
| 关键词 | drug design of Chinese medicine combination-activity relationship prescription discovery component identification formula optimization system modeling |
| 英文摘要 | The research and development (R&D) process of Chinese medicine, with one notable feature, clinical application based, is significantly different from which of chemical and biological medicine, from laboratory research to clinics. Besides, compound prescription is another character. Therefore, according to different R&D theories between Chinese and Western medicine, we put forward a new strategy in drug design of Chinese medicine, which focuses on "combination-activity relationship (CAR)", taking prescription discovery, component identification and formula optimization as three key points to identify the drugs of high efficacy and low toxicity. The method of drug design of Chinese medicine includes: new prescription discovery based on clinical data and literature information, component identification based on computing and experimental research, as well as formula optimization based on system modeling. This paper puts forward the concept, research framework and techniques of drug design of Chinese medicine, which embodies the R&D model of Chinese medicine, hoping to support the drug design of Chinese medicine theoretically and technologically. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Integrative & Complementary Medicine |
| 研究领域[WOS] | Integrative & Complementary Medicine |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310224500001 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4151]  |
| 专题 | 自动化研究所_综合信息系统研究中心 |
| 作者单位 | 1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100290, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang Hong-jun,Shen Dan,Xu Hai-yu,et al. A new strategy in drug design of chinese medicine: Theory, method and techniques[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2012,18(11):803-806. |
| APA | Yang Hong-jun,Shen Dan,Xu Hai-yu,&Lu Peng.(2012).A new strategy in drug design of chinese medicine: Theory, method and techniques.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,18(11),803-806. |
| MLA | Yang Hong-jun,et al."A new strategy in drug design of chinese medicine: Theory, method and techniques".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 18.11(2012):803-806. |
入库方式： OAI收割
来源：自动化研究所
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