A Computational Drug-Target Network for Yuanhu Zhitong Prescription
文献类型：期刊论文
| 作者 | Xu, Haiyu1; Tao, Ye1,2; Lu, Peng1,3 ; Wang, Peng2; Zhang, Fangbo1; Yuan, Yuan1; Wang, Songsong4; Xiao, Xuefeng2; Yang, Hongjun1; Huang, Luqi1
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| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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| 出版日期 | 2013 |
| 英文摘要 | Yuanhu Zhitong prescription (YZP) is a typical and relatively simple traditional Chinese medicine (TCM), widely used in the clinical treatment of headache, gastralgia, and dysmenorrhea. However, the underlying molecular mechanism of action of YZP is not clear. In this study, based on the previous chemical and metabolite analysis, a complex approach including the prediction of the structure of metabolite, high-throughput in silico screening, and network reconstruction and analysis was developed to obtain a computational drug-target network for YZP. This was followed by a functional and pathway analysis by ClueGO to determine some of the pharmacologic activities. Further, two new pharmacologic actions, antidepressant and antianxiety, of YZP were validated by animal experiments using zebrafish and mice models. The forced swimming test and the tail suspension test demonstrated that YZP at the doses of 4 mg/kg and 8 mg/kg had better antidepressive activity when compared with the control group. The anxiolytic activity experiment showed that YZP at the doses of 100 mg/L, 150 mg/L, and 200 mg/L had significant decrease in diving compared to controls. These results not only shed light on the better understanding of the molecular mechanisms of YZP for curing diseases, but also provide some evidence for exploring the classic TCM formulas for new clinical application. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Integrative & Complementary Medicine |
| 研究领域[WOS] | Integrative & Complementary Medicine |
| 关键词[WOS] | TANDEM MASS-SPECTROMETRY ; CHINESE MEDICINE ; PREDICTION ; PAIN ; DEPRESSION ; ZEBRAFISH ; RECEPTOR ; SYSTEM ; MODEL ; MICE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319159700001 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4156]  |
| 专题 | 自动化研究所_综合信息系统研究中心 |
| 作者单位 | 1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 2.Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.Capital Med Univ, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Haiyu,Tao, Ye,Lu, Peng,et al. A Computational Drug-Target Network for Yuanhu Zhitong Prescription[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013. |
| APA | Xu, Haiyu.,Tao, Ye.,Lu, Peng.,Wang, Peng.,Zhang, Fangbo.,...&Huang, Luqi.(2013).A Computational Drug-Target Network for Yuanhu Zhitong Prescription.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. |
| MLA | Xu, Haiyu,et al."A Computational Drug-Target Network for Yuanhu Zhitong Prescription".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013). |
入库方式： OAI收割
来源：自动化研究所
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