A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism
文献类型：期刊论文
| 作者 | Dai, Wen1; Liu, Xi1; Zhang, Zhichen2; Chen, Jianxin3; Guo, Rongjuan2; Zheng, Hong2; Jin, Xianglan2; Wen, Shaoxin1 ; Gao, Yibo1; Li, Tiangang3
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| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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| 出版日期 | 2013 |
| 英文摘要 | Prompt and accurate diagnosis of acute ischemic stroke is critical to seek acute therapy. In traditional Chinese medicine (TCM) science, there is a comprehensive system of diagnosis and medical care of acute ischemic stroke. Here we introduce a two-level model for the analysis of TCM syndrome of acute ischemic stroke. Owing to the limitation of sample size and imbalance, we focused on the analysis of wind-phlegm collateral obstruction syndrome (Feng Tan Yu Zu Zheng). Firstly, a Support-Vector-Machine( SVM-) based diagnostic model was set up through selection of core symptoms. After pairwise undersampling, we improved the performance of prediction and generated the core symptoms-based diagnostic model of wind-phlegm collateral obstruction syndrome. Next, Pathway Pattern-based method and MetaDrug platform were used to shed light on the molecular basis of the significance of core symptoms in three complementary aspects: symptom-gene-pathway multilayer correlation network, enriched pathways, and most relevant interaction network. The integration of diagnostic model and molecular mechanism analysis creates an interesting perspective for better understanding the syndrome. The two-level model would provide a new opportunity for the study of TCM syndromes. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Integrative & Complementary Medicine |
| 研究领域[WOS] | Integrative & Complementary Medicine |
| 关键词[WOS] | SUPPORT VECTOR MACHINES ; HUMAN PHENOTYPE ONTOLOGY ; DRUG-METABOLISM ; PREDICTION ; TOXICITY ; EPISODES ; DISEASE ; SYMPTOM ; BRAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317506000001 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/4157]  |
| 专题 | 自动化研究所_综合信息系统研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.Beijing Univ Chinese Med, Dongfang Hosp, Beijing 100029, Peoples R China 3.Beijing Univ Chinese Med, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Wen,Liu, Xi,Zhang, Zhichen,et al. A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013. |
| APA | Dai, Wen.,Liu, Xi.,Zhang, Zhichen.,Chen, Jianxin.,Guo, Rongjuan.,...&Zhang, Yunling.(2013).A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. |
| MLA | Dai, Wen,et al."A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013). |
入库方式： OAI收割
来源：自动化研究所
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