Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery
文献类型：期刊论文
| 作者 | Wang, Lianyan; Yang, Tingyuan; Ma, Guanghui |
| 刊名 | CURRENT PHARMACEUTICAL DESIGN
 |
| 出版日期 | 2015 |
| 卷号 | 21期号:19页码:2563-2598 |
| 关键词 | Membrane emulsification protein/peptide drugs microparticle adjuvant bioactivity |
| ISSN号 | 1381-6128 |
| 英文摘要 | Biodegradable particles have important applications in Drug Delivery Systems (DDS) of protein/peptide drugs. And recently, particle systems have also showed to be powerful for vaccine delivery (adjuvant) in order to solve the difficulties when conventional Alum adjuvant was used. However, in above applications, the problems of broad size distribution and poor reproducibility of particles, and deactivation of protein during the preparation, storage and release, are still big challenges. Furthermore, particle should be designed specially according to antigen type and purpose in vaccine delivery. In this article, the techniques to control the diameter of microparticle (MP) will be introduced at the first, and then the strategies about how to maintain the bioactivity of protein drugs during preparation and drug release will be reviewed. Furthermore, particle application specially designed for vaccine delivery to enhance both humoral response and cellular response, will be described. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | SIZED CHITOSAN MICROSPHERES ; SOLVENT EVAPORATION METHOD ; MEDIATED IMMUNE-RESPONSES ; DOUBLE EMULSION TECHNIQUE ; LOADED PLGA MICROSPHERES ; ORAL DELIVERY ; IN-VITRO ; CONTROLLED-RELEASE ; PLA MICROCAPSULES ; DENDRITIC CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354609400004 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/19249]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lianyan,Yang, Tingyuan,Ma, Guanghui. Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery[J]. CURRENT PHARMACEUTICAL DESIGN,2015,21(19):2563-2598. |
| APA | Wang, Lianyan,Yang, Tingyuan,&Ma, Guanghui.(2015).Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery.CURRENT PHARMACEUTICAL DESIGN,21(19),2563-2598. |
| MLA | Wang, Lianyan,et al."Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery".CURRENT PHARMACEUTICAL DESIGN 21.19(2015):2563-2598. |
入库方式： OAI收割
来源：过程工程研究所
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