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A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1 alpha Activation in Pancreatic beta Cells
文献类型：期刊论文
| 作者 | Qiu, Yifu; Mao, Ting; Zhang, Yongliang; Shao, Mengle; You, Jia; Ding, QiuRong（丁秋蓉） ; Chen, Yan（陈雁）; Wu, Dongmei; Xie, Dong（谢东）; Lin, Xu（林旭）
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| 刊名 | SCIENCE SIGNALING
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| 出版日期 | 2010 |
| 卷号 | 3期号:106页码:ra7 |
| 通讯作者 | Liu, Y (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutrit Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China. |
| 英文摘要 | Autophosphorylation of inositol-requiring enzyme 1 alpha (IRE1 alpha) is required for its activation, which elicits the cellular unfolded protein response (UPR) and is functionally connected with insulin biosynthesis in pancreatic beta cells. We found that the scaffold protein receptor for activated C-kinase 1 (RACK1) interacted with IRE1 alpha in a glucose-stimulated or endoplasmic reticulum (ER) stress-responsive manner in pancreatic beta cells and primary islets. RACK1 mediated the glucose-inducible assembly of a complex containing IRE1 alpha, RACK1, and protein phosphatase 2A (PP2A) to promote dephosphorylation of IRE1 alpha by PP2A, thereby inhibiting glucose-stimulated IRE1 alpha activation and attenuating IRE1 alpha-dependent increases in insulin production. Moreover, IRE1 alpha activation was increased and RACK1 abundance was decreased in a mouse model of diabetes. Thus, our findings demonstrate that RACK1 functions as a key component in regulating the IRE1 alpha signaling pathway in pancreatic beta cells. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | UNFOLDED-PROTEIN RESPONSE ; ENDOPLASMIC-RETICULUM STRESS ; TRANSCRIPTION FACTOR XBP-1 ; MESSENGER-RNA ; ER STRESS ; TRANSMEMBRANE PROTEIN ; INSULIN-SECRETION ; MAMMALIAN-CELLS ; KINASE IRE1 ; RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275647400003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/102]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 中国科学院上海生命科学研究院营养科学研究所_营养与肿瘤分子生物学研究组 |
| 推荐引用方式 GB/T 7714 | Qiu, Yifu,Mao, Ting,Zhang, Yongliang,et al. A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1 alpha Activation in Pancreatic beta Cells[J]. SCIENCE SIGNALING,2010,3(106):ra7. |
| APA | Qiu, Yifu.,Mao, Ting.,Zhang, Yongliang.,Shao, Mengle.,You, Jia.,...&Liu, Yong.(2010).A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1 alpha Activation in Pancreatic beta Cells.SCIENCE SIGNALING,3(106),ra7. |
| MLA | Qiu, Yifu,et al."A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1 alpha Activation in Pancreatic beta Cells".SCIENCE SIGNALING 3.106(2010):ra7. |
入库方式： OAI收割
来源：上海营养与健康研究所
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