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Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism
文献类型：期刊论文
| 作者 | Han, R.; Lai, R.; Ding, QiuRong（丁秋蓉） ; Wang, Z.; Luo, X.; Zhang, Y.; Cui, G.; He, J.; Liu, W.; Chen,Yan（陈雁）
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| 刊名 | DIABETOLOGIA
 |
| 出版日期 | 2007 |
| 卷号 | 50期号:9页码:1960-1968 |
| 关键词 | AMP-activated protein kinase AMPK apolipoprotein A-I APOA-I endocytosis fat mass glucose homeostasis insulin resistance Type 2 diabetes |
| 通讯作者 | Chen, Y (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China. |
| 英文摘要 | Aims/hypothesis In humans, one of the hallmarks of type 2 diabetes is a reduced plasma concentration of HDL and its major protein component, apolipoprotein A-I (APOA-I). However, it is unknown whether APOA-I directly protects against diabetes. The aim of this study was to characterise the functional role of APOA-I in glucose homeostasis. Methods The effects of APOA-I on phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC), glucose uptake and endocytosis were analysed in C2C12 myocytes. Glucose metabolism was investigated in Apoa-I knockout (Apoa-I (-/-)) mice. Results APOA-I was able to stimulate the phosphorylation of AMPK and ACC, and elevated glucose uptake in C2C12 myocytes. APOA-I could be endocytosed into C2C12 myotubes through a clathrin-dependent endocytotic process. Inhibition of endocytosis abrogated APOA-I-stimulated AMPK phosphorylation. In Apoa-I-/- mice, AMPK phosphorylation was reduced in skeletal muscle and liver, and expression of gluconeogenic enzymes was increased in liver. In addition, the Apoa-I-/- mice had increased fat content and compromised glucose tolerance. Conclusions/interpretation Our data indicate that APOA-I has a protective effect against diabetes via activation of AMPK. ApoA-I deletion in the mouse led to increased fat mass and impaired glucose tolerance. |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | HIGH-DENSITY-LIPOPROTEIN ; CARDIOVASCULAR-DISEASE ; MEDIATED ENDOCYTOSIS ; INSULIN-RESISTANCE ; GENE-EXPRESSION ; GLOBULAR DOMAIN ; RECEPTOR ; ASSOCIATION ; ADIPONECTIN ; HDL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248771800021 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/104]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Han, R.,Lai, R.,Ding, QiuRong,et al. Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism[J]. DIABETOLOGIA,2007,50(9):1960-1968. |
| APA | Han, R..,Lai, R..,Ding, QiuRong.,Wang, Z..,Luo, X..,...&Chen,Yan.(2007).Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism.DIABETOLOGIA,50(9),1960-1968. |
| MLA | Han, R.,et al."Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism".DIABETOLOGIA 50.9(2007):1960-1968. |
入库方式： OAI收割
来源：上海营养与健康研究所
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