H-1 NMR investigation on interaction between ibuprofen and lipoproteins
文献类型：期刊论文
| 作者 | Lan, Wenxian; Zhu, Hang; Zhou, Zhiming; Ye, Chaohui; Liu, Maili |
| 刊名 | CHEMISTRY AND PHYSICS OF LIPIDS
 |
| 出版日期 | 2007-08-01 |
| 卷号 | 148期号:2页码:105-111 |
| 关键词 | NMR lipoprotein ibuprofen antioxidant interaction affinity |
| 英文摘要 | A large number of studies indicate that oxidative modification of plasma lipoproteins, especially low-density lipoprotein (LDL), is a critical factor in initiation and progression of atherosclerosis. We have previously found that ibuprofen (IBP), a potential antioxidant drug to inhibit LDL oxidation, interacted with lipoproteins in intact human plasma. In the present study, we compare the binding affinities of IBP to LDL and HDL (high-density lipoprotein) by H-1 NMR spectroscopy. When IBP is added into the HDL and LDL samples, the -N+(CH3)(3) moieties of phosphatidylcholine (PC) and sphingomyelin (SM) in lipoprotein particles experience the chemical shift up-field drift. Intermolecular cross-peaks observed in NOESY spectra imply that there are direct interactions between ibuprofen and lipoproteins at both hydrophobic and hydrophilic (ionic) regions. These interactions are likely to be important in the solubility of ibuprofen into lipoprotein particles. Ibuprofen has higher impact on the PC and SM head group (-N+(CH3)(3)) and -(CH2)(n-) group in HDL than that in LDL. This could be explained by either IBP has higher binding affinity to HDL than to LDL, or IBP induces orientation of the phospholipid head group at the surface of the lipoprotein particles. (C) 2007 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | LOW-DENSITY-LIPOPROTEIN ; NUCLEAR-MAGNETIC-RESONANCE ; CORONARY-HEART-DISEASE ; NMR-SPECTROSCOPY ; OXIDATIVE MODIFICATION ; SECONDARY PREVENTION ; BLOOD-PLASMA ; HUMAN SERUM ; VITAMIN-E ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248433600008 |
| 公开日期 | 2015-09-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/7809]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lan, Wenxian,Zhu, Hang,Zhou, Zhiming,et al. H-1 NMR investigation on interaction between ibuprofen and lipoproteins[J]. CHEMISTRY AND PHYSICS OF LIPIDS,2007,148(2):105-111. |
| APA | Lan, Wenxian,Zhu, Hang,Zhou, Zhiming,Ye, Chaohui,&Liu, Maili.(2007).H-1 NMR investigation on interaction between ibuprofen and lipoproteins.CHEMISTRY AND PHYSICS OF LIPIDS,148(2),105-111. |
| MLA | Lan, Wenxian,et al."H-1 NMR investigation on interaction between ibuprofen and lipoproteins".CHEMISTRY AND PHYSICS OF LIPIDS 148.2(2007):105-111. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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