Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?
文献类型：期刊论文
| 作者 | Dazzan, Paola1; Chan, Raymond C. K.2
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| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 56期号:32页码:3372-3375 |
| 关键词 | schizophrenia neurological soft signs motor dysfunction basal ganglia cognition |
| ISSN号 | 1001-6538 |
| 产权排序 | 2 |
| 通讯作者 | Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England. |
| 英文摘要 | Approximately 60% of subjects with schizophrenia present minor neurological signs (neurological soft signs, NSS), which include abnormalities in sensory and motor performance indicative of a non-specific cerebral dysfunction. These are also present in healthy individuals and relatives of patients with psychosis, at significantly lower rates. The excess of NSS in psychosis may be a potential endophenotype for this disorder, and reflect the same neurodevelopmental brain dysfunction that also underlies the cognitive deficits consistently reported in psychosis. To establish whether neurological and cognitive dysfunction meet the essential criterion required for a refined endophenotype for psychosis, the association with the illness, we explored evidence that certain neurological and cognitive deficits co-occur in affected individuals. This evidence suggests that signs of motor dysfunctions may be specific to patients with psychosis, in whom they are associated with dysfunction in cognitive tasks requiring motor skills. Thus, they may form a promising candidate endophenotype for psychosis. |
| 学科主题 | Abnormal psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the BIAL Foundation, a NARSAD Young Investigator Award, and a NARSAD Independent Investigator Award to Dr. P. Dazzan. Also, The Project-Oriented Hundred Talents Programme (O7CX031003), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131, KSCX2-EW-J-8), a grant from the National Basic Research Program of China (2007CB512302), and the National Science Fund for Distinguished Young Scholars (81088001) to Prof. R. C. K Chan. |
| 原文出处 | http://www.cnki.com.cn/Article/CJFDTotal-JXTW201132005.htm |
| 语种 | 英语 |
| WOS记录号 | WOS:000296641800003 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13333]  |
| 专题 | 心理研究所_脑与认知科学国家重点实验室 |
| 作者单位 | 1.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England 2.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dazzan, Paola,Chan, Raymond C. K.. Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3372-3375. |
| APA | Dazzan, Paola,&Chan, Raymond C. K..(2011).Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?.CHINESE SCIENCE BULLETIN,56(32),3372-3375. |
| MLA | Dazzan, Paola,et al."Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?".CHINESE SCIENCE BULLETIN 56.32(2011):3372-3375. |
入库方式： OAI收割
来源：心理研究所
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