Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats
文献类型：期刊论文
| 作者 | Dong, Xinwen1,2 ; Li, Yonghui2; Kirouac, Gilbert J.1,3
|
| 刊名 | FRONTIERS IN BEHAVIORAL NEUROSCIENCE
 |
| 出版日期 | 2015-06-16 |
| 卷号 | 9期号:0页码:161 |
| 关键词 | paraventricular nucleus fear orexin learning midline thalamus |
| ISSN号 | 1662-5153 |
| 英文摘要 | The paraventricular nucleus of the thalamus (PVT) projects to the central nucleus of the amygdala and recent experimental evidence indicates a role for the PVT in conditioned fear. Furthermore, the PVT contains a high density of orexin receptors and fibers and acute injections of orexin antagonist into the PVT produce anxiolytic effects. The present study was done to determine if administration of a dual orexin receptor antagonist (DORA) in the region of the PVT interferes with the expression of conditioned fear in rats exposed to cued and contextual conditioning paradigms. Infusion of 0.5 mu l of the DORA N-biphenyl-2-yl-1-[(1-methyl-1H-benzimidazol-2yl) sulfanyl] acetyl-L-prolinamide at a concentration of 0.1, 1.0, and 10 nmol had no effect on the freezing produced by exposing rats to an auditory cue or the context associated with foot shock. In contrast, the 1.0 and 10 nmol doses were anxiolytic in the social interaction test. The results of the present study do not support a role for orexin receptors in the PVT in the expression of learned fear. The finding that the 1.0 and 10 nmol doses of DORA in the PVT region were anxiolytic in the social interaction test is consistent with other studies indicating a role for orexins in the PVT in anxiety-like behaviors. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356788000001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13348]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Univ Manitoba, Fac Hlth Sci, Coll Dent, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Manitoba, Fac Hlth Sci, Coll Med, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada |
| 推荐引用方式 GB/T 7714 | Dong, Xinwen,Li, Yonghui,Kirouac, Gilbert J.. Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2015,9(0):161. |
| APA | Dong, Xinwen,Li, Yonghui,&Kirouac, Gilbert J..(2015).Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,9(0),161. |
| MLA | Dong, Xinwen,et al."Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 9.0(2015):161. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。