White Matter Abnormalities in Major Depression: A Tract-Based Spatial Statistics and Rumination Study
文献类型：期刊论文
| 作者 | Zuo, Nianming1; Fang, Jiliang2; Lv, Xueyu3; Zhou, Yuan4 ; Hong, Yang2; Li, Tao3; Tong, Haibing2; Wang, Xiaoling2; Wang, Weidong3; Jiang, Tianzi1,5,6
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| 刊名 | PLOS ONE
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| 出版日期 | 2012-05-30 |
| 卷号 | 7期号:5 |
| ISSN号 | 1932-6203 |
| 产权排序 | 4 |
| 通讯作者 | Zuo, NM (reprint author), Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, LIAMA Ctr Computat Med, Beijing, Peoples R China. |
| 英文摘要 | Increasing evidence indicates that major depressive disorder (MDD) is usually accompanied by altered white matter in the prefrontal cortex, the parietal lobe and the limbic system. As a behavioral abnormity of MDD, rumination has been believed to be a substantial indicator of the mental state of the depressive state. So far, however, no report that we are aware of has evaluated the relationship between white matter alterations and the ruminative state. In this study, we first explored the altered white matter using a tract-based spatial statistics (TBSS) method based on diffusion tensor imaging of 19 healthy and 16 depressive subjects. We then investigated correlations between the altered white matter microstructure in the identified altered regions and the severity of ruminations measured by the ruminative response scale. Our results demonstrated altered white matter microstructure in circuits connecting the prefrontal lobe, the parietal lobe and the limbic system (p<0.005, uncorrected), findings which support previous research. More importantly, the result also indicated that a greater alteration in the white matter is associated with a more ruminative state (p<0.05, Bonferroni corrected). The detected abnormalities in the white matter should be interpreted cautiously because of the small sample size in this study. This finding supports the psychometric significance of white matter deficits in MDD. |
| 学科主题 | Physiological psychology/Biological Psychology,Abnormal psychology |
| 收录类别 | SCI |
| 项目简介 | This work was partially supported by the Natural Science Foundation of China, Grant Nos. 81000634, 30772845, 30870668, 60831004, and National Institutes of Health/National Center for Complementary and Alternative Medicine (F05 AT003022-01-04), USA. No additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| 原文出处 | http://www.nlpr.ia.ac.cn/2012papers/gjkw/gk85.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000305353400033 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13334]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, LIAMA Ctr Computat Med, Beijing, Peoples R China 2.China Acad Chinese Med Sci, Guang An Men Hosp, Dept Radiol, Lab Funct Brain Imaging, Beijing, Peoples R China 3.China Acad Chinese Med Sci, Guang An Men Hosp, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab Neuroinformat, Minist Educ, Chengdu 610054, Peoples R China 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
| 推荐引用方式 GB/T 7714 | Zuo, Nianming,Fang, Jiliang,Lv, Xueyu,et al. White Matter Abnormalities in Major Depression: A Tract-Based Spatial Statistics and Rumination Study[J]. PLOS ONE,2012,7(5). |
| APA | Zuo, Nianming.,Fang, Jiliang.,Lv, Xueyu.,Zhou, Yuan.,Hong, Yang.,...&Jiang, Tianzi.(2012).White Matter Abnormalities in Major Depression: A Tract-Based Spatial Statistics and Rumination Study.PLOS ONE,7(5). |
| MLA | Zuo, Nianming,et al."White Matter Abnormalities in Major Depression: A Tract-Based Spatial Statistics and Rumination Study".PLOS ONE 7.5(2012). |
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来源：心理研究所
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