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High salt primes a specific activation state of macrophages, M(Na)
文献类型：期刊论文
| 作者 | Zhang, Wu-Chang; Zheng, Xiao-Jun; Du, Lin-Juan; Sun, Jian-Yong; Shen, Zhu-Xia; Shi, Chaoji; Sun, Shuyang; Zhang, Zhiyuan; Chen, Xiao-qing; Qin, Mu |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2015 |
| 卷号 | 25期号:8页码:893-910 |
| 关键词 | high salt macrophage activation acute lung injury |
| 英文摘要 | High salt is positively associated with the risk of many diseases. However, little is known about the mechanisms. Here we showed that high salt increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human and mouse macrophages. High salt also potentiated lipopolysaccharide-induced macrophage activation and suppressed interleukin 4-induced macrophage activation. High salt induced the proinflammatory aspects by activating p38/cFos and/or Erk1/2/cFos pathways, while inhibited the anti-inflammatory and proendocytic aspects by Erk1/2/signal transducer and activator of transcription 6 pathway. Consistent with the in vitro results, high-salt diet increased proinflammatory gene expression of mouse alveolar macrophages. In mouse models of acute lung injury, high-salt diet aggravated lipopolysaccharide-induced pulmonary macrophage activation and inflammation in lungs. These results identify a novel macrophage activation state, M(Na), and high salt as a potential environmental risk factor for lung inflammation through the induction of M(Na). |
| 类目[WOS] | Cell Biology |
| 研究领域[WOS] | Cell Biology |
| 关键词[WOS] | PATHOGENIC T(H)17 CELLS ; BLOOD-PRESSURE ; MAP KINASE ; SENSITIVE HYPERTENSION ; POTASSIUM EXCRETION ; URINARY SODIUM ; IMMUNE CELLS ; LUNG INJURY ; C-FOS ; POLARIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000358941100005 |
| 公开日期 | 2015-09-08 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/133]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_核受体与代谢和疾病研究组 中国科学院上海生命科学研究院营养科学研究所_营养与代谢性疾病中的基因表达调控研究组 中国科学院上海生命科学研究院营养科学研究所_磷脂代谢与心血管疾病研究组 中国科学院上海生命科学研究院营养科学研究所_心脏发育与再生研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Wu-Chang,Zheng, Xiao-Jun,Du, Lin-Juan,et al. High salt primes a specific activation state of macrophages, M(Na)[J]. CELL RESEARCH,2015,25(8):893-910. |
| APA | Zhang, Wu-Chang.,Zheng, Xiao-Jun.,Du, Lin-Juan.,Sun, Jian-Yong.,Shen, Zhu-Xia.,...&Duan, ShengZhong.(2015).High salt primes a specific activation state of macrophages, M(Na).CELL RESEARCH,25(8),893-910. |
| MLA | Zhang, Wu-Chang,et al."High salt primes a specific activation state of macrophages, M(Na)".CELL RESEARCH 25.8(2015):893-910. |
入库方式： OAI收割
来源：上海营养与健康研究所
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