Histology subtypes and polyp size are associated with synchronous colorectal carcinoma of colorectal serrated polyps: a study of 499 serrated polyps
文献类型：期刊论文
| 作者 | Zhu, Hailong; Zhang, Guofeng; Yi, Xianghua; Zhu, Xuyou; Wu, Yunjin; Liang, Jun; Zhang, Suxia; Zeng, Yu; Fan, Desheng; Yu, Xiaoting |
| 刊名 | AMERICAN JOURNAL OF CANCER RESEARCH
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:1页码:363-374 |
| 关键词 | Conventional adenoma sessile serrated adenoma traditional serrated adenoma hyperplastic polyp colon |
| 英文摘要 | Sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA) are considered as precursors of colorectal cancer, and are often diagnostic challenges. Their true prevalence is masked by significant interobserver variations. To investigate the true prevalence and synchronous colorectal carcinoma (sCRC) of colorectal serrated polyps (CSP) and their associated factors, we first retrospectively identified all colorectal polyps collected at our institution between June 1995 and May 2013. After centrally reclassifying all CSP to reduce inter-observer variations, Chi-square tests and logistic regression analyses were used to analyze the potential factors. Among the included 5501 colorectal polyps, 499 CSP of 428 patients were identified and studied, including 353 hyperplastic polyps (HP, 70.7%), 80 SSA (16.0%), 61 TSA (12.2%) and 5 mixed polyp (1.0%). Diagnostic disagreements were found in 68 CSP (13.63% of CSP). SSA and TSA were more often larger than 5 mm and in proximal colon than HP. SSA were also more likely associated with older age (p=0.005), size >= 5 mm (p<0.001) and >= 3 polyps (p=0.004) than HP in distal colon, but only more likely associated with older age (p=0.006) in proximal colon. Multivariate regression analysis demonstrated that CSP with sCRC, compared with CSP without sCRC, were linked to CSP size >= 1 cm (vs <1 cm, odds ratio [OR] 4.412, 95% confidence interval [CI] 1.684-11.556, P=0.003) and a diagnosis of SSA or TSA (vs HP, OR 6.194, 95% CI 1.870-20.513, P=0.003 and OR 6.754, 95% CI 1.981-23.028, P=0.002, respectively), but not age, gender, polyp number and polyp shape. SSA and TSA are similarly often associated with sCRC (P=0.460). In conclusion, histology subtypes and polyp size may serve as markers for sCRC of CSP. SSA and TSA may warrant careful endoscopic examinations and similar follow-up intervals. |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | BARRETTS-ESOPHAGUS ; GASTROENTEROLOGY GUIDELINES ; COLONOSCOPY SURVEILLANCE ; SCREENING COLONOSCOPY ; ADVANCED NEOPLASIA ; BRITISH-SOCIETY ; PROXIMAL COLON ; ADENOMAS ; PREVALENCE ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000348300400029 |
| 公开日期 | 2015-09-08 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/136]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_核受体与代谢和疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhu, Hailong,Zhang, Guofeng,Yi, Xianghua,et al. Histology subtypes and polyp size are associated with synchronous colorectal carcinoma of colorectal serrated polyps: a study of 499 serrated polyps[J]. AMERICAN JOURNAL OF CANCER RESEARCH,2015,5(1):363-374. |
| APA | Zhu, Hailong.,Zhang, Guofeng.,Yi, Xianghua.,Zhu, Xuyou.,Wu, Yunjin.,...&Zhang, Lanjing.(2015).Histology subtypes and polyp size are associated with synchronous colorectal carcinoma of colorectal serrated polyps: a study of 499 serrated polyps.AMERICAN JOURNAL OF CANCER RESEARCH,5(1),363-374. |
| MLA | Zhu, Hailong,et al."Histology subtypes and polyp size are associated with synchronous colorectal carcinoma of colorectal serrated polyps: a study of 499 serrated polyps".AMERICAN JOURNAL OF CANCER RESEARCH 5.1(2015):363-374. |
入库方式： OAI收割
来源：上海营养与健康研究所
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