Myeloid Mineralocorticoid Receptor Deficiency Inhibits Aortic Constriction-Induced Cardiac Hypertrophy in Mice
文献类型：期刊论文
| 作者 | Li, Chao; Zhang, Yu Yao; Frieler, Ryan A.; Zheng, Xiao Jun; Zhang, Wu Chang; Sun, Xue Nan; Yang, Qing Zhen; Ma, Shu Min; Huang, Baozhuan; Berger, Stefan |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:10页码:e110950 |
| 英文摘要 | Mineralocorticoid receptor (MR) blockade has been shown to suppress cardiac hypertrophy and remodeling in animal models of pressure overload (POL). This study aims to determine whether MR deficiency in myeloid cells modulates aortic constriction-induced cardiovascular injuries. Myeloid MR knockout (MMRKO) mice and littermate control mice were subjected to abdominal aortic constriction (AAC) or sham operation. We found that AAC-induced cardiac hypertrophy and fibrosis were significantly attenuated in MMRKO mice. Expression of genes important in generating reactive oxygen species was decreased in MMRKO mice, while that of manganese superoxide dismutase increased. Furthermore, expression of genes important in cardiac metabolism was increased in MMRKO hearts. Macrophage infiltration in the heart was inhibited and expression of inflammatory genes was decreased in MMRKO mice. In addition, aortic fibrosis and inflammation were attenuated in MMRKO mice. Taken together, our data indicated that MR deficiency in myeloid cells effectively attenuated aortic constriction-induced cardiac hypertrophy and fibrosis, as well as aortic fibrosis and inflammation. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | SELECTIVE ALDOSTERONE BLOCKER ; HEART-FAILURE ; OXIDATIVE STRESS ; NADPH OXIDASE ; MYOCARDIAL-INFARCTION ; PRESSURE-OVERLOAD ; BLOOD-PRESSURE ; INFLAMMATION ; ATHEROSCLEROSIS ; DYSFUNCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345204200048 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/139]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_核受体与代谢和疾病研究组 中国科学院上海生命科学研究院营养科学研究所_磷脂代谢与心血管疾病研究组 |
| 推荐引用方式 GB/T 7714 | Li, Chao,Zhang, Yu Yao,Frieler, Ryan A.,et al. Myeloid Mineralocorticoid Receptor Deficiency Inhibits Aortic Constriction-Induced Cardiac Hypertrophy in Mice[J]. PLOS ONE,2014,9(10):e110950. |
| APA | Li, Chao.,Zhang, Yu Yao.,Frieler, Ryan A..,Zheng, Xiao Jun.,Zhang, Wu Chang.,...&Mortensen, Richard M..(2014).Myeloid Mineralocorticoid Receptor Deficiency Inhibits Aortic Constriction-Induced Cardiac Hypertrophy in Mice.PLOS ONE,9(10),e110950. |
| MLA | Li, Chao,et al."Myeloid Mineralocorticoid Receptor Deficiency Inhibits Aortic Constriction-Induced Cardiac Hypertrophy in Mice".PLOS ONE 9.10(2014):e110950. |
入库方式： OAI收割
来源：上海营养与健康研究所
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