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Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice
文献类型：期刊论文
| 作者 | Usher, Michael G.; Duan, ShengZhong（段胜仲） ; Ivaschenko, Christine Y.; Frieler, Ryan A.; Berger, Stefan; Schuetz, Guenther; Lumeng, Carey N.; Mortensen, Richard M.
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| 刊名 | JOURNAL OF CLINICAL INVESTIGATION
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| 出版日期 | 2010 |
| 卷号 | 120期号:9页码:3350-3364 |
| 英文摘要 | Inappropriate excess of the steroid hormone aldosterone, which is a mineralocorticoid receptor (MR) agonist, is associated with increased inflammation and risk of cardiovascular disease. MR antagonists are cardioprotective and antiinflammatory in vivo, and evidence suggests that they mediate these effects in part by aldosterone-independent mechanisms. Here we have shown that MR on myeloid cells is necessary for efficient classical macrophage activation by proinflarnmatory cytokines. Macrophages from mice lacking MR in myeloid cells (referred to herein as MyMRKO mice) exhibited a transcription profile of alternative activation. In vitro, MR deficiency synergized with inducers of alternatively activated macrophages (for example, IL-4 and agonists of PPAR gamma and the glucocorticoid receptor) to enhance alternative activation. In vivo, MR deficiency in macrophages mimicked the effects of MR antagonists and protected against cardiac hypertrophy, fibrosis, and vascular damage caused by L-NAME/Ang II. Increased blood pressure and heart rates and decreased circadian variation were observed during treatment of MyMRKO mice with L-NAME/Ang II. We conclude that myeloid MR is an important control point in macrophage polarization and that the function of MR on myeloid cells likely represents a conserved ancestral MR function that is integrated in a transcriptional network with PPAR gamma and glucocorticoid receptor. Furthermore, myeloid MR is critical for blood pressure control and for hypertrophic and fibrotic responses in the mouse heart and aorta. |
| 类目[WOS] | Medicine, Research & Experimental |
| 研究领域[WOS] | Research & Experimental Medicine |
| 关键词[WOS] | PPAR-GAMMA ; MYOCARDIAL-INFARCTION ; INSULIN SENSITIVITY ; CARDIAC FIBROSIS ; GENE-EXPRESSION ; BLOOD-PRESSURE ; HEART-FAILURE ; ALTERNATIVE ACTIVATION ; EPLERENONE ; RESISTANCE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281458800037 |
| 公开日期 | 2015-09-08 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/143]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_核受体与代谢和疾病研究组 |
| 推荐引用方式 GB/T 7714 | Usher, Michael G.,Duan, ShengZhong,Ivaschenko, Christine Y.,et al. Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice[J]. JOURNAL OF CLINICAL INVESTIGATION,2010,120(9):3350-3364. |
| APA | Usher, Michael G..,Duan, ShengZhong.,Ivaschenko, Christine Y..,Frieler, Ryan A..,Berger, Stefan.,...&Mortensen, Richard M..(2010).Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice.JOURNAL OF CLINICAL INVESTIGATION,120(9),3350-3364. |
| MLA | Usher, Michael G.,et al."Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice".JOURNAL OF CLINICAL INVESTIGATION 120.9(2010):3350-3364. |
入库方式： OAI收割
来源：上海营养与健康研究所
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