Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut
文献类型：期刊论文
| 作者 | Lin, Juan1,2; Chen, Jun1; He, Jun1,2; Chen, Jing1,2; Yan, Qingyun3; Zhou, Jizhong4; Xie, Ping1 |
| 刊名 | TOXICON
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 95期号:1页码:50-56 |
| 关键词 | Microcystin-LR Rat gut Microbial functional gene GeoChip |
| ISSN号 | 0041-0101 |
| 通讯作者 | Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China. |
| 英文摘要 | The short-term exposure to microcystin-LR (MC-LR, one of the most common and toxic variants generated by toxigenic cyanobacteria) induced gut dysfunction such as generation of reactive oxygen species, cell erosion and deficient intestinal absorption of nutrients. However, till now, little is known about its impact on gut microbial community, which has been considered as necessary metabolic assistant and stresses resistant entities for the host. This study was designed to reveal the shift of microbial functional genes in the gut of rat orally gavaged with MC-LR. GeoChip detected a high diversity of bacterial and fungal genes involved in basic metabolic processes and stress resistance. The results showed that the composition of functional genes was significantly changed in rat gut after one week of exposure to MC-LR, and we found some relatively enriched genes that are involved in carbon degradation including chitin, starch and limonene metabolism, and these genes were mainly derived from fungal and bacterial pathogens. In addition, we found large amounts of significantly enriched genes relevant to degradation of the specific carbon compounds, aromatics. The dysbiosis of bacterial and fungal flora gave an implication of pathogens invasion. The enriched gene functions could be linked to acute gastroenteritis induced by MC-LR. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | PROTEIN PHOSPHATASE-1 ; ANAEROBIC DEGRADATION ; CANDIDA-ALBICANS ; MICROBIOTA ; VIRULENCE ; HEALTH ; INFLAMMATION ; EXPRESSION ; RESPONSES ; PATTERNS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350922700006 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23867]  |
| 专题 | 水生生物研究所_淡水生态学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 10049, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan, Peoples R China 4.Univ Oklahoma, Dept Microbiol & Plant Biol, Inst Environm Genom, Norman, OK 73019 USA |
| 推荐引用方式 GB/T 7714 | Lin, Juan,Chen, Jun,He, Jun,et al. Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut[J]. TOXICON,2015,95(1):50-56. |
| APA | Lin, Juan.,Chen, Jun.,He, Jun.,Chen, Jing.,Yan, Qingyun.,...&Xie, Ping.(2015).Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut.TOXICON,95(1),50-56. |
| MLA | Lin, Juan,et al."Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut".TOXICON 95.1(2015):50-56. |
入库方式： OAI收割
来源：水生生物研究所
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