Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-Dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae
文献类型：期刊论文
| 作者 | Wang, Qiangwei1,2; Lai, Nelson Lok-Shun3,4,5; Wang, Xianfeng1,2; Guo, Yongyong1; Lam, Paul Kwan-Sing3,4,5; Lam, James Chung-Wah4; Zhou, Bingsheng1 |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2015-04-21 |
| 卷号 | 49期号:8页码:5123-5132 |
| ISSN号 | 0013-936X |
| 通讯作者 | Lam, JCW (reprint author), City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China. |
| 英文摘要 | Organophosphate flame retardants are emerging environmental contaminants, although knowledge of their health risks is limited. Here, thyroid hormone homeostasis and neuronal development was studied in the progeny of adult zebrafish exposed to tris(1,3-dichloro-2-propyl) phosphate (TDCPP). Adult zebrafish were exposed to TDCPP (0, 4, 20, and 100 mu g/L) for 3 months. Increased generation of a reactive oxygen species and reduced survival rates was observed in exposed F1 larvae. We also observed a significant decrease in plasma thyroxine and 3,5,3'-triiodothyronine levels in F0 females and F1 eggs/larvae. The mRNA and protein expression of factors associated with neuronal development (e.g., alpha 1-tubulin, myelin basic protein, and synapsin ha) were significantly downregulated in exposed F1 larvae, as was the level of the neurotransmitters dopamine, serotonin, gamma amino butyric acid, and histamine. Larval locomotion was significantly decreased in exposed fish, but there was no effect on acetylcholinesterase activity. Bioconcentration of TDCPP was observed in F0 fish. TDCPP was also detected in F1 eggs following parental exposure, indicating maternal transfer of this compound. This study uniquely shows that TDCPP can be transferred to the offspring of exposed adults, causing thyroid endocrine disruption and developmental neurotoxicity. |
| WOS标题词 | Science & Technology ; Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Engineering, Environmental ; Environmental Sciences |
| 研究领域[WOS] | Engineering ; Environmental Sciences & Ecology |
| 关键词[WOS] | POLYBROMINATED DIPHENYL ETHERS ; MESSENGER-RNA EXPRESSION ; MATERNAL TRANSFER ; TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE ; HORMONE-LEVELS ; POLYCHLORINATED-BIPHENYLS ; ENVIRONMENTAL CHEMICALS ; TISSUE DISTRIBUTION ; MASS-SPECTROMETRY ; SOUTH CHINA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353610300041 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23938]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China 4.City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen Key Lab Sustainable Use Marine Biodivers, Shenzhen 518057, Guangdong, Peoples R China 5.City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qiangwei,Lai, Nelson Lok-Shun,Wang, Xianfeng,et al. Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-Dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2015,49(8):5123-5132. |
| APA | Wang, Qiangwei.,Lai, Nelson Lok-Shun.,Wang, Xianfeng.,Guo, Yongyong.,Lam, Paul Kwan-Sing.,...&Zhou, Bingsheng.(2015).Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-Dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae.ENVIRONMENTAL SCIENCE & TECHNOLOGY,49(8),5123-5132. |
| MLA | Wang, Qiangwei,et al."Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-Dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae".ENVIRONMENTAL SCIENCE & TECHNOLOGY 49.8(2015):5123-5132. |
入库方式： OAI收割
来源：水生生物研究所
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