Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae
文献类型：期刊论文
| 作者 | Miao, Wei1; Zhu, Biran2,3; Xiao, Xiaohong4; Li, Ying1; Dirbaba, Niguse Bekele1; Zhou, Bingsheng2; Wu, Hongjuan1 |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2015-04-01 |
| 卷号 | 161页码:117-126 |
| 关键词 | Pb Titanium dioxide nanoparticles Bioconcentration Thyroid disruption Developmental neurotoxicity Zebrafish larvae |
| ISSN号 | 0166-445X |
| 通讯作者 | Wu, HJ (reprint author), Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, 1037 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China. |
| 英文摘要 | Nanoparticles (NPs) have attracted considerable attention because of their wide range of applications. Interactions between heavy metals (e.g., Pb) and NPs in aquatic environments may modify the bioavailability and toxicity of heavy metals. Therefore, this study investigated the influence of NPs (e.g., nano-TiO2) on the bioavailability and toxicity of Pb and its effects in the thyroid endocrine and nervous systems of zebrafish (Danio rerio) larvae. Zebrafish embryos (2-h post-fertilization) were exposed to five concentrations of Pb alone (0, 5, 10, 20, and 30 mu g/L) or in combination with nano-TiO2 (0.1 mg/L) until 6 days post-fertilization. Results showed that the bioconcentration of Pb was significantly enhanced when combined with nano-TiO2 than when used alone. Zebrafish exposure to Pb alone at 30 mu g/L significantly decreased the thyroid hormone levels (T-4 and T-3), whereas nano-TiO2 treatment alone did not produce detectable changes. The levels of T-4 and T-3 were further decreased when Pb was combined with nano-TiO2 than when used alone. The transcription of the thyroid hormone-related factor tg gene was remarkably down-regulated by Pb treatment alone but up-regulated when Pb was combined with nano-TiO2. The significant up-regulation of tsh beta gene and the down-regulation of TTR gene expression in the hypothalamic-pituitary-thyroid were observed in Pb with or without nano-TiO2 treatment groups. In addition, the transcription of genes involved in central nervous system (CNS) development (a-tubulin, mbp, gfap and shha) were significantly down-regulated by Pb and nano-TiO2 co-exposure as compared with Pb exposure alone. The locomotion activity analyzes confirmed that nano-TiO2 might enhance the toxicity of Pb to CNS development. These results suggest that nano-TiO2 increase bioconcentration of lead, which lead to the disruption of thyroid endocrine and neuronal system in zebrafish larvae. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Marine & Freshwater Biology ; Toxicology |
| 研究领域[WOS] | Marine & Freshwater Biology ; Toxicology |
| 关键词[WOS] | DECABROMODIPHENYL ETHER BDE-209 ; GENE-EXPRESSION ; HEAVY-METALS ; SONIC HEDGEHOG ; DAPHNIA-MAGNA ; AQUEOUS SUSPENSIONS ; RAINBOW-TROUT ; PEARL RIVER ; RAT-BRAIN ; EXPOSURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352177500014 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23943]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 4.China Univ Petr East China, Coll Mech & Elect Engn, Qingdao 266580, Peoples R China |
| 推荐引用方式 GB/T 7714 | Miao, Wei,Zhu, Biran,Xiao, Xiaohong,et al. Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2015,161:117-126. |
| APA | Miao, Wei.,Zhu, Biran.,Xiao, Xiaohong.,Li, Ying.,Dirbaba, Niguse Bekele.,...&Wu, Hongjuan.(2015).Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae.AQUATIC TOXICOLOGY,161,117-126. |
| MLA | Miao, Wei,et al."Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae".AQUATIC TOXICOLOGY 161(2015):117-126. |
入库方式： OAI收割
来源：水生生物研究所
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