Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae
文献类型：期刊论文
| 作者 | Zhu, Biran1,2; Wang, Qiangwei1,2; Wang, Xianfeng1,2; Zhou, Bingsheng1 |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 157页码:186-195 |
| 关键词 | Pb BDE-209 Co-exposure Thyroid disruption Thyroid hormones Synergistic effects |
| ISSN号 | 0166-445X |
| 通讯作者 | Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China. |
| 英文摘要 | Polybrominated diphenyl ethers (PBDEs) and metals are the main contaminants at waste electrical and electronic equipment ("e-waste") recycling sites. However, the potential environmental health effects of mixtures of PBDEs and metals are not known. We investigated co-exposure of lead (Pb) with decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Seven groups of embryos/larvae of zebrafish were treated with Pb (0, 2, 5, 10, 15, 20, and 30 mu g/L), six groups were exposed to BDE-209 (0, 50, 100, 200, 400, and 800 mu g/L), and nine groups of zebrafish larvae were treated with Pb and BDE-209 (5, 10, and 20 mu g/L Pb; 50, 100, and 200 mu g/L BDE-209). Embryos/larvae were exposed from 2 h post-fertilization (hpf) until 144 hpf, and thyroid hormone (TH) content measured. Pb exposure significantly decreased whole-body TH contents (triiodothyroxine (T-3) and thyroxine (T-4)) but BDE-209 exposure significantly increased T-3 and T-4 levels. Pb or BDE-209 treatment alone caused a predicted downregulation of TH transport (i.e., expression of the mRNA or proteins of transthyretin). Chemical analyses showed Pb uptake to be increased by BDE-209, but BDE-209 bioconcentration was decreased and the ability to metabolize BDE-209 was reduced in the presence of Pb. We also found that a mixture of the two chemicals had a synergistic effect on TH levels in zebrafish. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Marine & Freshwater Biology ; Toxicology |
| 研究领域[WOS] | Marine & Freshwater Biology ; Toxicology |
| 关键词[WOS] | POLYBROMINATED DIPHENYL ETHERS ; PEARL RIVER DELTA ; BROMINATED FLAME RETARDANTS ; TROUT ONCORHYNCHUS-MYKISS ; WASTE DISMANTLING REGION ; ELECTRONIC-WASTE ; SOUTH CHINA ; ENDOCRINE DISRUPTION ; POLYCHLORINATED-BIPHENYLS ; DEVELOPMENTAL EXPOSURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346547800020 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23959]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Biran,Wang, Qiangwei,Wang, Xianfeng,et al. Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2014,157:186-195. |
| APA | Zhu, Biran,Wang, Qiangwei,Wang, Xianfeng,&Zhou, Bingsheng.(2014).Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae.AQUATIC TOXICOLOGY,157,186-195. |
| MLA | Zhu, Biran,et al."Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae".AQUATIC TOXICOLOGY 157(2014):186-195. |
入库方式： OAI收割
来源：水生生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。