FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity
文献类型：期刊论文
| 作者 | Mei, Zhichao1; Zhang, Dawei1; Hu, Bo1; Wang, Jing1; Shen, Xian3; Xiao, Wuhan1,2 |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2015-06-26 |
| 卷号 | 290期号:26页码:16202-16214 |
| 关键词 | cell proliferation muscle atrophy Myc (c-Myc) oncogene ubiquitylation (ubiquitination) FBXO32 proteasomal degradation |
| ISSN号 | 0021-9258 |
| 通讯作者 | Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China. |
| 英文摘要 | Background: FBXO32 is an E3 ubiquitin ligase that plays important roles in tumorigenesis and muscle atrophy. Results: c-Myc was found to be a target of FBXO32 for proteasomal degradation. Conclusion: FBXO32 targets Lys-326 of c-Myc to form polyubiquitin chains, resulting in inhibition of cell proliferation. Significance: FBXO32 may mediate c-Myc proteasomal degradation. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | SKELETAL-MUSCLE ATROPHY ; FOXO TRANSCRIPTION FACTORS ; UBIQUITIN LIGASE ; DEPENDENT DEGRADATION ; PROTEIN EXPRESSION ; TUMOR-SUPPRESSOR ; GENE-EXPRESSION ; MESSENGER-RNA ; PHOSPHORYLATION ; IDENTIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356930100024 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23968]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 3.Wenzhou Med Univ, Hosp 1, Wenzhou 325000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mei, Zhichao,Zhang, Dawei,Hu, Bo,et al. FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(26):16202-16214. |
| APA | Mei, Zhichao,Zhang, Dawei,Hu, Bo,Wang, Jing,Shen, Xian,&Xiao, Wuhan.(2015).FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity.JOURNAL OF BIOLOGICAL CHEMISTRY,290(26),16202-16214. |
| MLA | Mei, Zhichao,et al."FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity".JOURNAL OF BIOLOGICAL CHEMISTRY 290.26(2015):16202-16214. |
入库方式： OAI收割
来源：水生生物研究所
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