Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish
文献类型：期刊论文
| 作者 | Cheng, Xiaoxia1,2; Chen, Xiaowen1; Li, Dongliang1,2; Jin, Xia1; He, Jiangyan1; Yin, Zhan1 |
| 刊名 | GENERAL AND COMPARATIVE ENDOCRINOLOGY
 |
| 出版日期 | 2015-04-01 |
| 卷号 | 214页码:87-94 |
| 关键词 | Pomca expression Metronidazole Zebrafish Endocrine interference |
| ISSN号 | 0016-6480 |
| 通讯作者 | Yin, Z (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China. |
| 英文摘要 | The Metronidazole (MTZ), a widely used antibiotic for treating variations of infections, recently is applied in a powerful tool for specifically ablating cells or tissues when combined with E. coil nitroreductase (NTR). Although some undesired biological effects on eukaryote cells have been reported previously, the toxicological mechanism of MTZ has not been uncovered yet. In current study, we found that MTZ can induce proopiomelanocortin a (pomca) expression in zebrafish larvae. The effect of MTZ is in stage-sensitive and dose-dependent manner. A pro-proliferation activity of MTZ on pomca-expressing cells in the pituitary at larval stage was also observed. Furthermore, up-regulated levels of prolactin (prl) and glycoprotein hormone subunit alpha (gsu alpha) were also observed after the MTZ treatment. Therefore, utilizing our zebrafish as in vivo model, we concluded that MTZ can interfere the endocrine signals in the pituitary hormone genes expression. Our current results raised the cautions to the intensively application of MTZ in clinical practices and biomedical researches. (C) 2014 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | TRANSGENIC ZEBRAFISH ; BACTEROIDES INFECTIONS ; DISRUPTING CHEMICALS ; TARGETED ABLATION ; CELL ABLATION ; NITROREDUCTASE ; MODEL ; REGENERATION ; PREVENTION ; DEATH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353844300012 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23980]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Xiaoxia,Chen, Xiaowen,Li, Dongliang,et al. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2015,214:87-94. |
| APA | Cheng, Xiaoxia,Chen, Xiaowen,Li, Dongliang,Jin, Xia,He, Jiangyan,&Yin, Zhan.(2015).Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish.GENERAL AND COMPARATIVE ENDOCRINOLOGY,214,87-94. |
| MLA | Cheng, Xiaoxia,et al."Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish".GENERAL AND COMPARATIVE ENDOCRINOLOGY 214(2015):87-94. |
入库方式： OAI收割
来源：水生生物研究所
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