Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish
文献类型：期刊论文
| 作者 | Yang, Xiaojie1,2; Gu, Qilin1,2; Lin, Li3; Li, Shaoyang3; Zhong, Shan3; Li, Qing1; Cui, Zongbin1 |
| 刊名 | MOLECULAR AND CELLULAR BIOLOGY
 |
| 出版日期 | 2015-04-01 |
| 卷号 | 35期号:7页码:1110-1124 |
| ISSN号 | 0270-7306 |
| 通讯作者 | Li, Q (reprint author), Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China. |
| 英文摘要 | Nucleoporin p62 (Nup62) localizes in the central channel of nuclear pore complexes (NPCs) and regulates nuclear pore permeability and nucleocytoplasmic transport. However, the developmental roles of Nup62 in vertebrates remain largely unclear. Zebrafish Nup62-like protein (Nup62l) is a homolog of mammalian Nup62. The nup62l gene is maternally expressed, but its transcripts are ubiquitously distributed during early embryogenesis and enriched in the head, pharynx, and intestine of developing embryos. Activation of the Wnt/beta-catenin pathway positively modulates nup62l transcription, while Bmp signaling acts downstream of Wnt/b-catenin signaling to negatively regulate nup62l expression. Overexpression of nup62l dorsalized embryos and enhanced gastrula convergence and extension (CE) movements. In contrast, knockdown of Nup62l led to ventralized embryos, an impediment to CE movements, and defects in specification of midline organ progenitors. Mechanistically, Nup62l acts as an activator of Wnt/beta-catenin signaling through interaction with and facilitation of nuclear import of beta-catenin-1/2 in zebrafish. Thus, Nup62l regulates dorsoventral patterning, gastrula CE movements, and proper specification of midline organ precursors through mediating the nuclear import of beta-catenins in zebrafish. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | BONE MORPHOGENETIC PROTEINS ; PORE COMPLEX ; XENOPUS EMBRYOS ; NUCLEOCYTOPLASMIC TRANSPORT ; EXTENSION MOVEMENTS ; COLORECTAL-CANCER ; CELL MOVEMENTS ; AXIS FORMATION ; MESSENGER-RNA ; P62 COMPLEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351739200004 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23983]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Wuhan Univ, Sch Basic Med Sci, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaojie,Gu, Qilin,Lin, Li,et al. Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish[J]. MOLECULAR AND CELLULAR BIOLOGY,2015,35(7):1110-1124. |
| APA | Yang, Xiaojie.,Gu, Qilin.,Lin, Li.,Li, Shaoyang.,Zhong, Shan.,...&Cui, Zongbin.(2015).Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish.MOLECULAR AND CELLULAR BIOLOGY,35(7),1110-1124. |
| MLA | Yang, Xiaojie,et al."Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish".MOLECULAR AND CELLULAR BIOLOGY 35.7(2015):1110-1124. |
入库方式： OAI收割
来源：水生生物研究所
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