The hypoxia signaling pathway and hypoxic adaptation in fishes
文献类型：期刊论文
| 作者 | Xiao Wuhan |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2015-02-01 |
| 卷号 | 58期号:2页码:148-155 |
| 关键词 | hypoxia hypoxia-inducible factors PHDs pVHL FIH fish |
| ISSN号 | 1674-7305 |
| 通讯作者 | Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China. |
| 英文摘要 | The hypoxia signaling pathway is an evolutionarily conserved cellular signaling pathway present in animals ranging from Caenorhabditis elegans to mammals. The pathway is crucial for oxygen homeostasis maintenance. Hypoxia-inducible factors (HIF-1 alpha and HIF-2 alpha) are master regulators in the hypoxia signaling pathway. Oxygen concentrations vary a lot in the aquatic environment. To deal with this, fishes have adapted and developed varying strategies for living in hypoxic conditions. Investigations into the strategies and mechanisms of hypoxia adaptation in fishes will allow us to understand fish speciation and breed hypoxia-tolerant fish species/strains. This review summarizes the process of the hypoxia signaling pathway and its regulation, as well as the mechanism of hypoxia adaptation in fishes. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biology |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics |
| 关键词[WOS] | GOLDFISH CARASSIUS-AURATUS ; BASS DICENTRARCHUS-LABRAX ; FACTOR-ALPHA SUBUNITS ; INDUCIBLE-FACTOR ; GENE-EXPRESSION ; CRUCIAN CARP ; FACTOR HIF-1-ALPHA ; OXIDATIVE STRESS ; HIF-ALPHA ; TRANSCRIPTIONAL REGULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349407000004 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23989]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao Wuhan. The hypoxia signaling pathway and hypoxic adaptation in fishes[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(2):148-155. |
| APA | Xiao Wuhan.(2015).The hypoxia signaling pathway and hypoxic adaptation in fishes.SCIENCE CHINA-LIFE SCIENCES,58(2),148-155. |
| MLA | Xiao Wuhan."The hypoxia signaling pathway and hypoxic adaptation in fishes".SCIENCE CHINA-LIFE SCIENCES 58.2(2015):148-155. |
入库方式： OAI收割
来源：水生生物研究所
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