Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)
文献类型：期刊论文
| 作者 | Qi, Zhitao1,2; Jiang, Yousheng1,3; Holland, Jason W.1; Nie, Pin4; Secombes, Christopher J.1; Wang, Tiehui1 |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 44期号:2页码:389-398 |
| 关键词 | Rainbow trout Oncorhynchus mykiss Atypical chemokine receptor-2 (ACKR2) CC chemokine binding protein-2 (CCBP2) Expression Infection |
| ISSN号 | 1050-4648 |
| 通讯作者 | Wang, TH (reprint author), Univ Aberdeen, Inst Biol & Environm Sci, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland. |
| 英文摘要 | Atypical chemokine receptors (ACKRs) have emerged as key components of the chemokine system, with an essential regulatory function in innate and adaptive immune responses and inflammation. In mammals ACKR2 is a 'scavenging' receptor for inflammatory CC chemolcines and plays a central role in the resolution of in vivo inflammatory responses. An ACKR2 like gene has been identified and cloned in rainbow trout (Teleostei) in the present study, enabling the further identification of this molecule in another group of ray-finned teleost fish (Holostei), in a lobe-finned fish (Sarcopterygii-coelacanth), and in reptiles. The identity of these ACKR2 molecules is supported by their conserved structure, and by phylogenetic tree and synteny analysis. Trout ACKR2 is highly expressed in spleen and head kidney, suggesting a homeostatic role of this receptor in limiting the availability of its potential ligands. Trout ACKR2 expression can be modulated in vivo by bacterial and parasitic infections, and in vitro by PAMPs (poly I:C and peptidoglycan) and cytokines (IL-6, INF-alpha, IFN-gamma and IL-21) in a time dependent manner. These patterns of expression and modulation suggest that trout ACKR2 is regulated in a complex way and has an important role in control of the chemokine network in fish as in mammals. (c) 2015 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 关键词[WOS] | PROLIFERATIVE KIDNEY-DISEASE ; YERSINIA-RUCKERI INFECTION ; TELEOST FISH ; CC CHEMOKINES ; GENE-EXPRESSION ; FUNCTIONAL-CHARACTERIZATION ; ATLANTIC SALMON ; CYTOKINE FAMILY ; IFN-GAMMA ; EVOLUTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354583800001 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23893]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | 1.Univ Aberdeen, Inst Biol & Environm Sci, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland 2.Yancheng Inst Technol, Dept Ocean Technol, Key Lab Aquaculture & Ecol Coastal Pool Jiangsu P, Yancheng 224051, Jiangsu, Peoples R China 3.Shanghai Ocean Univ, Coll Fishery & Life Sci, Shanghai 201306, Peoples R China 4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Zhitao,Jiang, Yousheng,Holland, Jason W.,et al. Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)[J]. FISH & SHELLFISH IMMUNOLOGY,2015,44(2):389-398. |
| APA | Qi, Zhitao,Jiang, Yousheng,Holland, Jason W.,Nie, Pin,Secombes, Christopher J.,&Wang, Tiehui.(2015).Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss).FISH & SHELLFISH IMMUNOLOGY,44(2),389-398. |
| MLA | Qi, Zhitao,et al."Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)".FISH & SHELLFISH IMMUNOLOGY 44.2(2015):389-398. |
入库方式： OAI收割
来源：水生生物研究所
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