The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies
文献类型：期刊论文
| 作者 | Tang, Haipei1,2; Liu, Yun1,3,6; Luo, Daji4,5; Ogawa, Satoshi7; Yin, Yike2; Li, Shuisheng1,2; Zhang, Yong1,2,3; Hu, Wei4; Parhar, Ishwar S.7; Lin, Haoran1,2 |
| 刊名 | ENDOCRINOLOGY
 |
| 出版日期 | 2015-02-01 |
| 卷号 | 156期号:2页码:589-599 |
| ISSN号 | 0013-7227 |
| 通讯作者 | Cheng, CHK (reprint author), Chinese Univ Hong Kong, Room 604A,6-F, Shatin, Hong Kong, Peoples R China. |
| 英文摘要 | The kiss1/gpr54 signaling system is considered to be a critical regulator of reproduction in most vertebrates. However, this presumption has not been tested vigorously in nonmammalian vertebrates. Distinct from mammals, multiple kiss1/gpr54 paralogous genes (kiss/kissr) have been identified in nonmammalian vertebrates, raising the possibility of functional redundancy among these genes. In this study, we have systematically generated the zebrafish kiss1(-/-), kiss2(-/-), and kiss1(-/-); kiss2-/- mutant lines as well as the kissr1(-/-), kissr2(-/-), and kissr1(-/-); kissr2(-/-) mutant lines using transcription activator-like effector nucleases. We have demonstrated that spermatogenesis and folliculogenesis as well as reproductive capability are not impaired in all of these 6 mutant lines. Collectively, our results indicate that kiss/kissr signaling is not absolutely required for zebrafish reproduction, suggesting that the kiss/kissr systems play nonessential roles for reproduction in certain nonmammalian vertebrates. These findings also demonstrated that fish and mammals have evolved different strategies for neuroendocrine control of reproduction. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | GOLDFISH CARASSIUS-AURATUS ; KISSPEPTIN/KISSPEPTIN RECEPTOR SYSTEM ; MACKEREL SCOMBER-JAPONICUS ; GONADAL DEVELOPMENT ; NEUROENDOCRINE REGULATION ; GONADOTROPIN-SECRETION ; EVOLUTIONARY INSIGHTS ; TELEOST FISH ; KISSPEPTIN ; GPR54 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353131800019 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23896]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | 1.Sun Yat Sen Univ, Sch Life Sci, Inst Aquat Econ Anim, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Aquat Econ Anim, Guangzhou 510275, Guangdong, Peoples R China 3.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430070, Peoples R China 5.Wuhan Univ, Sch Basic Med Sci, Dept Genet, Wuhan 430072, Peoples R China 6.Chinese Univ Hong Kong, Shenzhen Res Inst, Sch Biomed Sci, Core Lab, Shenzhen 518057, Peoples R China 7.Monash Univ Malaysia, Sch Med & Hlth Sci, Brain Res Inst, Bandar Sunway 47500, Malaysia |
| 推荐引用方式 GB/T 7714 | Tang, Haipei,Liu, Yun,Luo, Daji,et al. The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies[J]. ENDOCRINOLOGY,2015,156(2):589-599. |
| APA | Tang, Haipei.,Liu, Yun.,Luo, Daji.,Ogawa, Satoshi.,Yin, Yike.,...&Cheng, Christopher H. K..(2015).The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies.ENDOCRINOLOGY,156(2),589-599. |
| MLA | Tang, Haipei,et al."The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies".ENDOCRINOLOGY 156.2(2015):589-599. |
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来源：水生生物研究所
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