Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish
文献类型：期刊论文
| 作者 | Zou, Peng Fei1,2; Chang, Ming Xian2; Li, Ying3; Zhang, Shu Huan2; Fu, Jian Ping2; Chen, Shan Nan2; Nie, Pin2 |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 43期号:1页码:13-24 |
| 关键词 | Retinoic acid-inducible gene-I Variant Type I IFN production Mitochondrial antiviral signaling protein RIG-lb/MAVS-mediated signaling pathway |
| ISSN号 | 1050-4648 |
| 通讯作者 | Chang, MX (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China. |
| 英文摘要 | As an intracellular pattern recognition receptor (PRR), the retinoic acid-inducible gene-I (RIG-I) is responsible for the recognition of cytosolic viral nucleic acids and the production of type I interferons (IFNs). In the present study, an insertion variant of RIG-I with 38 amino acids inserted in the N-terminal CARD2 domain, as well as the typical type, named as RIG-Ia and RIG-Ib respectively were identified in zebrafish. RIG-la and RIG-Ib were all up-regulated following the infection of a negative ssRNA virus, the Spring Viremia of Carp Virus (SVCV), and an intracellular Gram-negative bacterial pathogen Edwardsiella tarda, indicating the RLR may have a role in the recognition of both viruses and bacteria. The overexpression of RIG-Ib in cultured fish cells resulted in significant increase in type I IFN promoter activity, and in protection against SVCV infection, whereas the over-expression of RIG-Ia had no direct effect on IFN activation nor antiviral response. Furthermore, it was revealed that both RIG-Ia and RIG-Ib were associated with the downstream molecular mitochondrial antiviral signaling protein, MAVS, and interestingly RIG-Ia when co-transfected with RIG-Ib or MAVS, induced a significantly higher level of type IFN promoter activity and the expression level of Mx and IRF7, implying that the RIG-la may function as an enhancer in the RIG-Ib/MAVS-mediated signaling pathway. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 关键词[WOS] | INNATE IMMUNE-RESPONSE ; INDUCIBLE GENE-I ; PATHOGEN RECOGNITION ; VIRAL-INFECTION ; RNA VIRUSES ; MDA5 ; RECEPTORS ; ACTIVATION ; LGP2 ; IDENTIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349731400002 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/23906]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | 1.Jimei Univ, Coll Fisheries, Xiamen 361021, Fujian Province, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China 3.Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, Wuhan 430074, Hubei Province, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Peng Fei,Chang, Ming Xian,Li, Ying,et al. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish[J]. FISH & SHELLFISH IMMUNOLOGY,2015,43(1):13-24. |
| APA | Zou, Peng Fei.,Chang, Ming Xian.,Li, Ying.,Zhang, Shu Huan.,Fu, Jian Ping.,...&Nie, Pin.(2015).Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish.FISH & SHELLFISH IMMUNOLOGY,43(1),13-24. |
| MLA | Zou, Peng Fei,et al."Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish".FISH & SHELLFISH IMMUNOLOGY 43.1(2015):13-24. |
入库方式： OAI收割
来源：水生生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。