Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice
文献类型：期刊论文
| 作者 | Zhang, Limin1,2; Hatzakis, Emmanuel3; Nichols, Robert G.1; Hao, Ruixin1; Correll, Jared1; Smith, Philip B.4; Chiaro, Christopher R.1; Perdew, Gary H.1; Patterson, Andrew D.1 |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2015-07-07 |
| 卷号 | 49期号:13页码:8067-8077 |
| 英文摘要 | Environmental exposure to dioxins and dioxin-like compounds poses a significant health risk for human health. Developing a better understanding of the mechanisms of toxicity through activation of the aryl hydrocarbon receptor (AHR) is likely to improve the reliability of risk assessment. In this study, the AHR-dependent metabolic response of mice exposed to 2,3,7,8-tetrachlorodibenzofuran (TCDF) was assessed using global H-1 nuclear magnetic resonance (NMR)-based metabolomics and targeted metabolite profiling of extracts obtained from serum and liver. H-1 NMR analyses revealed that TCDF exposure suppressed gluconeogenesis and glycogenolysis, stimulated lipogenesis, and triggered inflammatory gene expression in an Ahr-dependent manner. Targeted analyses using gas chromatography coupled with mass spectrometry showed TCDF treatment altered the ratio of unsaturated/saturated fatty acids. Consistent with this observation, an increase in hepatic expression of stearoyl coenzyme A desaturase 1 was observed. In addition, TCDF exposure resulted in inhibition of de novo fatty acid biosynthesis manifested by down-regulation of acetyl-CoA, malonyl-CoA, and palmitoyl-CoA metabolites and related mRNA levels. In contrast, no significant changes in the levels of glucose and lipid were observed in serum and liver obtained from Ahr-null mice following TCDF treatment, thus strongly supporting the important role of the AHR in mediating the metabolic effects seen following TCDF exposure. |
| WOS标题词 | Science & Technology ; Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Engineering, Environmental ; Environmental Sciences |
| 研究领域[WOS] | Engineering ; Environmental Sciences & Ecology |
| 关键词[WOS] | REGULATORY T-CELLS ; FATTY-ACID ; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD ; METABONOMIC APPROACH ; RAT-LIVER ; TOXICITY ; DIOXIN ; IDENTIFICATION ; EXPRESSION ; RESPONSES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000357840300069 |
| 公开日期 | 2015-09-15 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/7826]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Penn State Univ, Ctr Mol Toxicol & Carcinogenesis, Dept Vet & Biomed Sci, University Pk, PA 16802 USA 2.Chinese Acad Sci, CAS Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Penn State Univ, Dept Chem, University Pk, PA 16802 USA 4.Penn State Univ, Metabol Facil, Huck Inst Life Sci, University Pk, PA 16802 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Limin,Hatzakis, Emmanuel,Nichols, Robert G.,et al. Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2015,49(13):8067-8077. |
| APA | Zhang, Limin.,Hatzakis, Emmanuel.,Nichols, Robert G..,Hao, Ruixin.,Correll, Jared.,...&Patterson, Andrew D..(2015).Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice.ENVIRONMENTAL SCIENCE & TECHNOLOGY,49(13),8067-8077. |
| MLA | Zhang, Limin,et al."Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice".ENVIRONMENTAL SCIENCE & TECHNOLOGY 49.13(2015):8067-8077. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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