Effect of temperature on the chromatographic behavior of epirubicin and its analogues on high purity silica using reversed-phase solvents
文献类型：期刊论文
| 作者 | Dong, Lili; Huang, Junxiong |
| 刊名 | CHROMATOGRAPHIA
 |
| 出版日期 | 2007-05 |
| 卷号 | 65期号:1页码:519-526 |
| 关键词 | column liquid chromatography high purity silica reversed-phase solvents temperature effects on retention van't Hoff plots |
| 英文摘要 | The influence of temperature on the retention behavior of epirubicin and its analogues on high purity silica with reversed-phase solvents has been systematically investigated. it was found that temperature effects on retention are highly dependent on the type and concentration of organic modifier, as well as the pH of the mobile phase. In organic-rich mobile phases, the type of organic modifier plays an important role. With an aprotic solvent as modifier, retention times show anomalous increases with elevated temperature. At the same time, both efficiency and resolution are significantly improved but this is not the situation with aprotic solvent as modifier. In addition, temperature shows different effects on retention time and selectivity when the pH is changed, and temperature-dependent selectivity reversal is found at higher pHs. In aqueous-rich mobile phases, regardless of the nature of the organic solvent and pH, retention of solutes drops as temperature is raised. It seems that the effect of temperature on chromatographic behavior of the solutes on bare silica using mobile phases containing various organic modifiers or pHs, results from a number of different retention mechanisms. |
| WOS记录号 | WOS:000246878900003 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22454]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Dong, Lili,Huang, Junxiong. Effect of temperature on the chromatographic behavior of epirubicin and its analogues on high purity silica using reversed-phase solvents[J]. CHROMATOGRAPHIA,2007,65(1):519-526. |
| APA | Dong, Lili,&Huang, Junxiong.(2007).Effect of temperature on the chromatographic behavior of epirubicin and its analogues on high purity silica using reversed-phase solvents.CHROMATOGRAPHIA,65(1),519-526. |
| MLA | Dong, Lili,et al."Effect of temperature on the chromatographic behavior of epirubicin and its analogues on high purity silica using reversed-phase solvents".CHROMATOGRAPHIA 65.1(2007):519-526. |
入库方式： OAI收割
来源：生态环境研究中心
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