Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones
文献类型：期刊论文
| 作者 | Zhu, Ben-Zhan ; Kalyanaraman, Balaraman ; Jiang, Gui-Bin |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2007-11-06 |
| 卷号 | 104期号:45页码:17575-17578 |
| 关键词 | ESR spin-trapping tetrachloro-1 tetrachlorosemiquinone anion radical Fenton reaction 4-benzoquinone |
| 英文摘要 | We have shown previously that hydroxyl radicals (HO center dot) can be produced by H2O2 and halogenated quinones, independent of transition metal ions; however, the underlying molecular mechanism is still unclear. In the present study, using the electron spin resonance secondary radical spin-trapping method, we found that tetrachloro-1,4-benzoquinone (TCBQ), but not its corresponding semiquinone anion radical, the tetrachlorosemiquinone anion radical (TCSQ(center dot-)), is essential for HO center dot production. The major reaction product between TCBQ and H2O2 was identified by electrospray ionization quadrupole time-of-flight mass spectrometry to be the ionic form of trichlorohydroxy-1,4-benzoquinone (TrCBQ-OH), and H2O2 was found to be the source and origin of the oxygen atom inserted into the reaction product TrCBQ-OH. On the basis of these data, we propose that HO center dot production by H2O2 and TCBQ is not through a semiquinone-dependent organic Fenton reaction but rather through the following mechanism: a nucleophilic attack of H2O2. to TCBQ, forming a trichlorohydroperoxyl-1,4-benzoquinone (TrCBQ-OOH) intermediate, which decomposes homolytically to produce HO center dot This represents a mechanism of HO center dot production that does not require redox-active transition metal ions. |
| WOS记录号 | WOS:000250897600007 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22481]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhu, Ben-Zhan,Kalyanaraman, Balaraman,Jiang, Gui-Bin. Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(45):17575-17578. |
| APA | Zhu, Ben-Zhan,Kalyanaraman, Balaraman,&Jiang, Gui-Bin.(2007).Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,104(45),17575-17578. |
| MLA | Zhu, Ben-Zhan,et al."Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104.45(2007):17575-17578. |
入库方式： OAI收割
来源：生态环境研究中心
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